Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 972-974
ZHONG Sheng-fen, ZHOU Wen-can, NI Miao-jun, ZHU Yu-qing, WEN Chao, JIN Ji, YANG Yu. Comparison of the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants[J]. Chinese Journal of General Practice, 2021, 19(6): 972-974. doi: 10.16766/j.cnki.issn.1674-4152.001963
Citation: ZHONG Sheng-fen, ZHOU Wen-can, NI Miao-jun, ZHU Yu-qing, WEN Chao, JIN Ji, YANG Yu. Comparison of the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants[J]. Chinese Journal of General Practice, 2021, 19(6): 972-974. doi: 10.16766/j.cnki.issn.1674-4152.001963
shu

Comparison of the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants

doi: 10.16766/j.cnki.issn.1674-4152.001963
  • 1.

    Pharmacy Department, Maternal and Child Health Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China

Funds:

 2019KY555

  • Received Date: 2020-04-15
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the effect of different antibiotic treatment regimens on intestinal microecology and peripheral blood T lymphocyte subsets in infants.   Methods  A total of 72 infants treated with antibiotics in the Maternal and Child Health Hospital of Fuyang District, Hangzhou from January 2019 to December 2019 were selected as the observation group. Meanwhile, 24 healthy infants not administered with antibiotics were selected as the control group. The intestinal microecology and peripheral blood T lymphocyte subsets in both groups were compared. Additionally, the effect of different antibiotic treatment regimens on the above indices in the observation group was compared.   Results  Differences in intestinal microecology and peripheral blood T lymphocyte subsets between the observation and control groups were significant (all P < 0.05). In the observation group, levels of lactobacilli and bifidobacteria were lower in infants treated with β-lactams combined with non-β-lactams antibiotics than those treated with β-lactams or non-β-lactams alone (all P < 0.05). The proportion of normal intestinal microflora in infants treated with β-lactams combined with non-β-lactams antibiotics (8.33%) was significantly lower than that in those treated with β-lactams (58.33%) or non-β-lactams (45.83%) alone (all P < 0.05). Besides, CD8+, CD3+ and CD4+ were lower than in those treated with β-lactams or non-β-lactams alone (all P < 0.05).   Conclusion  Treatment with β-lactams combined with non-β-lactams antibiotics greatly influences intestinal microecology and peripheral blood T lymphocyte subsets in infants.

     

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