Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder

ZHANG Fengfei; LU Yan; RUAN Zhuoer; ZOU Shengzhen; CHEN Jing

doi:10.16766/j.cnki.issn.1674-4152.004539

Volume 24 Issue 6

Jun. 2026

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Article Navigation > Chinese Journal of General Practice > 2026 > 24(6): 998-1001

ZHANG Fengfei, LU Yan, RUAN Zhuoer, ZOU Shengzhen, CHEN Jing. Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder[J]. Chinese Journal of General Practice, 2026, 24(6): 998-1001. doi: 10.16766/j.cnki.issn.1674-4152.004539

Citation:

ZHANG Fengfei, LU Yan, RUAN Zhuoer, ZOU Shengzhen, CHEN Jing. Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder[J]. Chinese Journal of General Practice, 2026, 24(6): 998-1001. doi: 10.16766/j.cnki.issn.1674-4152.004539

Citation:

ZHANG Fengfei, LU Yan, RUAN Zhuoer, ZOU Shengzhen, CHEN Jing. Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder[J]. Chinese Journal of General Practice, 2026, 24(6): 998-1001. doi: 10.16766/j.cnki.issn.1674-4152.004539

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Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder

doi: 10.16766/j.cnki.issn.1674-4152.004539

1.
Department of Psychiatry, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

2023KY1272

Received Date: 2026-01-06
Available Online: 2026-11-10

Abstract

Abstract

Objective To analyze the antidepressant effects and safety of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder, and to examine its impact on suicide risk and EEG wave amplitude. Methods A retrospective study was conducted, selecting 182 patients with major depressive disorder from the Second Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, between December 2023 and November 2025. The patients were divided into two groups based on different treatment methods: the control group (90 patients) who received EEG biofeedback therapy from December 2023 to October 2024, and the observation group (92 patients) who received EEG biofeedback therapy combined with relaxation therapy from November 2024 to November 2025. The clinical outcomes, depressive and anxiety symptoms, suicidal ideation, EEG wave amplitude, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 92.4% (85/92), which was higher than the [82.2% (74/90)] of the control group, and the difference was statistically significant (χ²=4.261, P=0.039); After treatment, the 24 Hamilton depression rating scale (HAMD-24) scores, Hamilton anxiety rating scale (HAMA), and psychiatric and psychological suicide risk assessment scale score in the observation group were all lower than those in the control group (P < 0.05); The observation group exhibited higher αwave power and lower δand θwave power compared to the control group (P < 0.05); There was no statistically significant difference in the comparison of adverse reactions between the two groups (P>0.05). Conclusion The combination of EEG biofeedback therapy and relaxation therapy has a good antidepressant effect and high safety in patients with severe depression. It can effectively alleviate patients' anxiety and depression, reduce suicidal ideation, and have a positive impact on patients' EEG waves.
- Severe depression,
- EEG biofeedback therapy,
- Relaxation therapy,
- Depression,
- Anxiety,
- Suicidal ideation

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References

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Analysis of the antidepressant effect of EEG biofeedback therapy combined with relaxation therapy in patients with major depressive disorder

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