Volume 24 Issue 6
Jun.  2026
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(6): 977-980
HU Jingjing, YANG Wenjuan, HE Ye, XU Xiaofeng, SHEN Qunshan. Analysis of pregnancy outcomes and predictive factors for miscarriage risk after transvaginal multifetal pregnancy reduction[J]. Chinese Journal of General Practice, 2026, 24(6): 977-980. doi: 10.16766/j.cnki.issn.1674-4152.004534
Citation: HU Jingjing, YANG Wenjuan, HE Ye, XU Xiaofeng, SHEN Qunshan. Analysis of pregnancy outcomes and predictive factors for miscarriage risk after transvaginal multifetal pregnancy reduction[J]. Chinese Journal of General Practice, 2026, 24(6): 977-980. doi: 10.16766/j.cnki.issn.1674-4152.004534
shu

Analysis of pregnancy outcomes and predictive factors for miscarriage risk after transvaginal multifetal pregnancy reduction

doi: 10.16766/j.cnki.issn.1674-4152.004534
  • 1.

    Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 82301896

  • Received Date: 2025-09-11
    Available Online: 2026-11-10
    Abstract
  •   Objective  To evaluate the safety and influencing factors of transvaginal ultrasound-guided multiple pregnancy reduction procedure (TV-MFPR).  Methods  A retrospective analysis was conducted on 338 pregnant women who underwent reduction surgery for multiple pregnancies after assisted reproductive technology at the First Affiliated Hospital of Anhui Medical University from March 2018 to May 2024. The clinical indicators were compared among groups based on the outcome, cause of miscarriage, and the number of surviving triplets. Logistic regression analysis of risk factors influencing miscarriage after reduction.  Results  Divided into the miscarriage group (LC, 36 cases) and the live birth group (FM, 302 cases) based on outcomes after reduction. The gestational age at reduction of the LC group [65.00 (61.00, 70.50) days vs. 61.00 (60.00, 64.00) days, Z=-3.475, P < 0.001], and the usage rate of KCL [15 cases (41.7%) vs. 40 cases (13.2%), P < 0.001] were all higher than those of the FM group. Logistic regression showed that the use of KCL (OR=0.318, P=0.009), each unit increase in BMI (OR=0.895, P= 0.022), and each delay of gestational age in reduction (OR=0.946, P=0.032) all increased the risk of miscarriage. The proportion of transferring two embryos in the single-embryo survival group and the rate of monozygotic twins were both significantly higher than those in the twin pregnancy group (P < 0.05). The incidence of complications during twin delivery was significantly higher in the live birth group than in the singleton group.  Conclusion  TV-MFPR is a safe and effective intervention method for multiple pregnancies after ART. It is recommended to perform early reduction at 7-9 weeks, control BMI, and use KCL with caution. The risk of complications in twin pregnancies is high, and individualized selection of reduction schemes and optimization of pregnancy outcomes are necessary.

     

    • FullText(HTML)
  • loading
    • References(15)
  • [1]
    DAHDOUH E M, ZREIK T G, GHNANME W, et al. Prevention of multiple pregnancies in gonadotropin-insemination cycles[J]. Curr Opin Obstet Gynecol, 2022, 34(3): 101-106. doi: 10.1097/GCO.0000000000000777
    [2]
    王凤英, 章翀, 尹宗智, 等. 跨专业共享决策在双胎妊娠孕妇中的应用研究[J]. 中华全科医学, 2025, 23(2): 198-202. doi: 10.16766/j.cnki.issn.1674-4152.003866

    Wang F Y, Zhang C, Yin Z Z, et al. Application of interprofessional shared decision-making in pregnant women with twin pregnancies[J]. Chinese Journal of General Practice, 2025, 23(2): 198-202. doi: 10.16766/j.cnki.issn.1674-4152.003866
    [3]
    PATUZZO M S, CASPRINI C, BOSCO M, et al. Voluntary multifetal pregnancy reduction: who should decide and select and why?[J]. Eur J Obstet Gynecol Reprod Biol, 2025, 308(4): 143-146.
    [4]
    冯银宏, 钱晶晶, 宋学军. 孕前体重指数、孕期体重增加与妊娠期并发症及妊娠结局的关系[J]. 中国现代医学杂志, 2021, 31(2): 92-96.

    Feng Y H, Qian J J, Song X J. Relationship between pre-pregnancy body mass index, gestational weight gain and pregnancy complications/pregnancy outcomes[J]. Chin J Mod Med, 2021, 31(2): 92-96.
    [5]
    PINBORG A, WENNERHOLM U B, BERGH C. Long-term outcomes for children conceived by assisted reproductive technology[J]. Fertil Steril, 2023, 120(3 Pt 1): 449-456.
    [6]
    CHEN Z, XIONG L, JIN H, et al. Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts[J]. Aging Cell, 2021, 20(7): e13417. DOI: 10.1111/acel.13417.
    [7]
    曹佳城, 肖扬, 王素霞. 多囊卵巢综合征不孕患者药物促排卵的风险与防治进展[J]. 中华全科医学, 2023, 21(5): 844-848. doi: 10.16766/j.cnki.issn.1674-4152.002997

    Cao J C, Xiao Y, Wang S X. Risks and prevention advances in drug-induced ovulation for infertile patients with polycystic ovary syndrome[J]. Chin J Gen Pract, 2023, 21(5): 844-848. doi: 10.16766/j.cnki.issn.1674-4152.002997
    [8]
    XIA S, YOU K, LIN M, et al. Intertwin nuchal translucency difference predicts the chance of co-twin death after fetal reduction in dichorionic triplet pregnancies: a retrospective analysis study[J]. BMC Pregnancy Childbirth, 2023, 23(1): 747. DOI: 10.1186/s12884-023-06064-9.
    [9]
    张红霞, 杨锐, 杨松, 等. 经颅胸内注射KCl对胎儿复位的影响[J]. 北京大学学报, 2022, 54(5): 943-947.

    Zhang H X, Yang R, Yang S, et al. Effects of transvaginal intrathoracic KCl injection on fetal reduction[J]. J Peking Univ(Health Sci), 2022, 54(5): 943-947.
    [10]
    LIU S, LI G, WANG C, et al. Pregnancy and obstetric outcomes of dichorionic and trichorionic triamniotic triplet pregnancy with multifetal pregnancy reduction: a retrospective analysis study[J]. BMC Pregnancy Childbirth, 2022, 22(1): 280. DOI: 10.1186/s12884-022-04617-y.
    [11]
    从艳艳, 沈曦, 匡延平. 高龄女性冻融胚胎移植中单个或双卵裂期胚胎与单个囊胚的活产率比较及相关影响因素[J]. 诊断学理论与实践, 2020, 19(1): 50-54.

    Cong Y Y, Shen X, Kuang Y P. Comparison of live birth rates and influencing factors between single/double cleavage-stage embryos and single blastocyst in frozen-thawed embryo transfer for advanced-age women[J]. Journal of Diagnostics Concepts & Practice, 2020, 19(1): 50-54.
    [12]
    LI N, SUN J, WANG J, et al. Selective termination of the fetus in multiple pregnancies using ultrasound-guided radiofrequency ablation[J]. BMC Pregnancy Childbirth, 2021, 21(1): 821. DOI: 10.1186/s12884-021-04285-4.
    [13]
    张轶乐, 孙莹璞, 苏迎春, 等. 早期与中期多胎妊娠减胎术妊娠结局分析[J]. 中华全科医学, 2011, 9(9): 1365-1366, 1461.

    Zhang Y L, Sun Y P, Su Y C, et al. Pregnancy outcomes analysis of multifetal pregnancy reduction in early versus mid-trimester[J]. Chin J Gen Pract, 2011, 9(9): 1365-1366, 1461.
    [14]
    XU Q, LI M, WANG X, et al. Dichorionic triamniotic triplets after two blastocysts transfer underwent multifetal pregnancy reduction: two case reports and literature review[J]. BMC Womens Health, 2024, 24(1): 492. DOI: 10.1186/s12905-024-03324-4.
    [15]
    任建枝, 沙爱国, 郑仁瑞, 等. 选择性减胎术在多胎妊娠中的应用[J]. 中国现代医学杂志, 2003, 13(11): 137-142.

    Ren J Z, Sha A G, Zheng R R, et al. Application of selective fetal reduction in multifetal pregnancies[J]. China Journal of Modern Medicine, 2003, 13(11): 137-142.
    • Relative Articles
    • Supplements(0)
    • Cited By

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (11) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return