Volume 24 Issue 6
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MA Yunlong, FU Yu. Effects and risk factors of diabetes and immunosuppressive state on surgical site deep infection after posterior lumbar interbody fusion surgery[J]. Chinese Journal of General Practice, 2026, 24(6): 932-935. doi: 10.16766/j.cnki.issn.1674-4152.004524
Citation: MA Yunlong, FU Yu. Effects and risk factors of diabetes and immunosuppressive state on surgical site deep infection after posterior lumbar interbody fusion surgery[J]. Chinese Journal of General Practice, 2026, 24(6): 932-935. doi: 10.16766/j.cnki.issn.1674-4152.004524
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Effects and risk factors of diabetes and immunosuppressive state on surgical site deep infection after posterior lumbar interbody fusion surgery

doi: 10.16766/j.cnki.issn.1674-4152.004524

  • Spinal Surgery Center, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010020, China

Funds:

 2024MS08072

  • Received Date: 2026-02-11
    Available Online: 2026-11-10
    Abstract
  •   Objective  To explore the relationship between diabetes (DM) and immunosuppressive state (IS) with deep surgical site infection (SSDI) after posterior lumbar fusion surgery, and to identify the related risk factors, in order to provide basis for the prevention and treatment of SSDI.  Methods  A retrospective analysis was conducted on the clinical data of 350 patients who underwent PLIF surgery in the Second Affiliated Hospital of Inner Mongolia Medical University from January 2020 to January 2025. According to whether patients had DM or (and) IS before the operation, the patients were divided into four groups: group A (n=90, DM), group B (n=46, IS), DM combined with IS (n=30, DM and IS), and No DM and no IS (n=184, neither DM nor IS). The incidence of SSDI in each group was compared, and they were grouped according to the presence or absence of SSDI. Univariate and multivariate logistic regression analyses were conducted to identify the risk factors for SSDI occurrence.  Results  The incidence of SSDI after surgery was 7.43% in the patients. A total of 35 pathogenic bacteria were detected, among which Staphylococcus aureus accounted for 60.00% (21/35). The incidences of SSDI after surgery in group A, group B, group C, and group D were 8.89%, 10.87%, 20.00%, and 3.80% respectively, and those in group C was significantly higher than that in group D (chi-square value, χ2=11.858, P < 0.008). Multivariate logistic regression analysis revealed that preoperative DM combined with IS (OR=4.600, 95% CI: 1.912-11.068), preoperative HbA1c level (OR=3.456, 95% CI: 1.654-7.221), and postoperative drainage time (OR=1.430, 95% CI: 1.058-1.934) were independent influencing factors for the occurrence of SSDI after surgery (P < 0.05).  Conclusion  DM and IS are important co-occurring risk factors for SSDI after PLIF surgery.

     

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