Volume 24 Issue 6
Jun.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(6): 922-925
TANG Jinling, ZHENG Shaochu, LUO Jin, LI Shang, XU Yang, KONG Jinliang. Investigation of the causal relationship between LGALS8 expression and bronchiectasis based on Mendelian randomization[J]. Chinese Journal of General Practice, 2026, 24(6): 922-925. doi: 10.16766/j.cnki.issn.1674-4152.004522
Citation: TANG Jinling, ZHENG Shaochu, LUO Jin, LI Shang, XU Yang, KONG Jinliang. Investigation of the causal relationship between LGALS8 expression and bronchiectasis based on Mendelian randomization[J]. Chinese Journal of General Practice, 2026, 24(6): 922-925. doi: 10.16766/j.cnki.issn.1674-4152.004522
shu

Investigation of the causal relationship between LGALS8 expression and bronchiectasis based on Mendelian randomization

doi: 10.16766/j.cnki.issn.1674-4152.004522

  • Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530000, China

Funds:

 82560016

  • Received Date: 2025-11-05
    Available Online: 2026-11-10
    Abstract
  •   Objective  To investigate the causal association between galectin-8 (LGALS8) and bronchiectasis using Mendelian randomization (MR) analysis and clinical sample validation.  Methods  MR analysis was performed using cis-expression quantitative trait locus (cis-eQTL) data of druggable genes, protein quantitative trait locus (pQTL) data, and bronchiectasis datasets. Peripheral blood samples were collected from 34 patients with non-cystic bronchiectasis and 23 healthy controls at the First Affiliated Hospital of Guangxi Medical University between July and October 2021. LGALS8 expression was measured by RT-qPCR and analyzed by age, sex, BMI, smoking status, bronchiectasis assessment of clinical impact (BACI) score, and E-FACED score.  Results  MR analysis showed that increased LGALS8 gene expression was associated with higher bronchiectasis risk (OR=1.122, 95% CI: 1.030-1.222, P=0.008), as was increased LGALS8 protein expression (OR=1.495, 95% CI: 1.161-1.924, P=0.002). No horizontal pleiotropy or heterogeneity was detected. RT-qPCR showed significantly elevated LGALS8 expression in patients than in controls (P<0.001), with an area under the receiver operating characteristic curve of 0.910 (95% CI: 0.808-0.995). LGALS8 expression also differed significantly between patients with mild and moderate-to-severe E-FACED scores (P=0.003).  Conclusion  LGALS8 expression was causally associated with bronchiectasis. LGALS8 expression is elevated in patients with bronchiectasis, potentially contributing to the onset and progression of the disease.

     

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