Volume 24 Issue 6
Jun.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(6): 918-921
GUO Haoran, SONG Mengyao, SUN Chen, XIA Qun, WANG Lei, PENG Ziyu, MA Lijuan, ZHOU Rui. Clinical features of children with chest tightness variant asthma and diagnostic value of EOS count, total IgE and pulmonary function in peripheral blood[J]. Chinese Journal of General Practice, 2026, 24(6): 918-921. doi: 10.16766/j.cnki.issn.1674-4152.004521
Citation: GUO Haoran, SONG Mengyao, SUN Chen, XIA Qun, WANG Lei, PENG Ziyu, MA Lijuan, ZHOU Rui. Clinical features of children with chest tightness variant asthma and diagnostic value of EOS count, total IgE and pulmonary function in peripheral blood[J]. Chinese Journal of General Practice, 2026, 24(6): 918-921. doi: 10.16766/j.cnki.issn.1674-4152.004521
shu

Clinical features of children with chest tightness variant asthma and diagnostic value of EOS count, total IgE and pulmonary function in peripheral blood

doi: 10.16766/j.cnki.issn.1674-4152.004521
  • 1.

    Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 AHIAI2023K02

 KJ2019A0342

 Byycx23041

  • Received Date: 2025-01-19
    Available Online: 2026-11-10
    Abstract
  •   Objective  To investigate the clinical characteristics of childhood chest tightness variant asthma (CTVA) and the diagnostic value of peripheral blood eosinophil (EOS) count, total IgE, and pulmonary function, so as to provide evidence for early identification of CTVA in children.  Methods  A total of 51 children with CTVA admitted to the First Affiliated Hospital of Bengbu Medical University from January 2023 to December 2024 were enrolled as the study subjects. In addition, 58 children with non-acute exacerbation typical asthma during the same period were selected as the CA group, and 40 healthy children served as the control group. Clinical data from the three groups were collected. Spearman correlation analysis was used to examine the correlations of peripheral blood EOS count and total IgE with pulmonary function parameters. Receiver operating characteristic (ROC) curves were plotted to analyze their diagnostic value for childhood CTVA.  Results  The age of onset in the CTVA group was 10.3 (8.8, 11.6) years, which was higher than that in the CA group [7.7 (6.4, 10.5) years, Z=-3.811, P < 0.05]. There were no statistically significant differences between the two groups in terms of disease duration, season of onset, history of comorbid allergic rhinitis, BMI, and various pulmonary function indices. The peripheral blood EOS count and total IgE in the CTVA group were lower than those in the CA group, but higher than those in the control group (P < 0.05). In the CTVA group, both peripheral blood EOS count and total IgE showed negative correlations with small airway parameters [maximal mid-expiratory flow (MMEF), forced expiratory flow at 50% of vital capacity (FEF50), forced expiratory flow at 75% of vital capacity (FEF75), r < 0, P < 0.05]. ROC curve analysis indicated that the optimal cutoff values for MMEF, FEF50, and FEF75 in the CTVA group were 76.4%, 68.3%, and 67.1%, respectively, while the optimal cutoff values for peripheral blood EOS count and total IgE were 0.12×109/L and 62.6 IU/mL, respectively. The area under the curve (AUC) for the combination of peripheral blood EOS count, total IgE, and the three small airway indices was 0.832 (95% CI: 0.731-0.907, P < 0.05), which was greater than the diagnostic efficacy of any single indicator.  Conclusion  The age of onset in children with CTVA is higher than that in children with CA. The combination of peripheral blood EOS count, total IgE, and small airway parameters can assist in the clinical diagnosis of CTVA in children.

     

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