Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory <i>Mycoplasma pneumoniae</i> pneumonia in children

ZHU Jiangwen; CHEN Xiaoqing; CHEN Hui; ZHUANG Sisi; ZHOU Chen; ZUO Lili

doi:10.16766/j.cnki.issn.1674-4152.004520

Volume 24 Issue 6

Jun. 2026

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Article Navigation > Chinese Journal of General Practice > 2026 > 24(6): 913-917

ZHU Jiangwen, CHEN Xiaoqing, CHEN Hui, ZHUANG Sisi, ZHOU Chen, ZUO Lili. Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2026, 24(6): 913-917. doi: 10.16766/j.cnki.issn.1674-4152.004520

Citation:

ZHU Jiangwen, CHEN Xiaoqing, CHEN Hui, ZHUANG Sisi, ZHOU Chen, ZUO Lili. Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2026, 24(6): 913-917. doi: 10.16766/j.cnki.issn.1674-4152.004520

Citation:

ZHU Jiangwen, CHEN Xiaoqing, CHEN Hui, ZHUANG Sisi, ZHOU Chen, ZUO Lili. Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children[J]. Chinese Journal of General Practice, 2026, 24(6): 913-917. doi: 10.16766/j.cnki.issn.1674-4152.004520

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Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children

doi: 10.16766/j.cnki.issn.1674-4152.004520

ZHU Jiangwen^{1, 2}
, CHEN Xiaoqing¹
, CHEN Hui¹
, ZHUANG Sisi¹
, ZHOU Chen¹
, ZUO Lili^{1
,
,}

1.
Department of Pediatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds:

K2023007

JSPH-MC-2023-30

Received Date: 2025-05-16
Available Online: 2026-11-10

Abstract

Abstract

Objective To evaluate the value of the lung ultrasound score (LUS), clinical pulmonary infection score (CPIS), and serum inflammatory markers in predicting the timing for bronchoalveolar lavage (BAL) intervention and the outcomes of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. Methods A prospective nested case-control study was conducted. Fifty children with MPP treated in the Department of Pediatrics of the First Affiliated Hospital of Nanjing Medical University from May 2023 to May 2024 were selected as the research subjects. The children were divided into the bronchoscopy group (BAL group, n=28) and the non-bronchoscopy group (non-BAL group, n=22) based on whether they received BAL intervention. Baseline data, LUS, CPIS, and serum inflammatory markers were compared between the two groups. A multivariate logistic regression model was constructed by combining the above indicators, and the receiver operating characteristic curve (ROC) was drawn to predict the timing of BAL intervention and the outcome of RMPP. Results There were no statistically significant differences in gender, age, weight, mean arterial pressure, blood gas [pH, arterial oxygen saturation (SaO₂), lactic acid (Lac)], and lactate dehydrogenase (LDH) between the two groups (P>0.05). The BAL group had higher LUS, CPIS, IL-6, D-dimer, fever days, and hospitalization days than the non-BAL group (P < 0.05). ROC analysis indicated that the area under the curve (AUC) of the model combining LUS≥26.5 points, CPIS≥5.5 points, and IL-6≥25.1 ng/L for predicting the timing of BAL intervention was 0.950, with a sensitivity of 89.3% and a specificity of 95.0% (P < 0.05). The AUC of the model combining LUS≥27.5 points, CPIS≥6.5 points, and IL-6 ≥ 30.6 ng/L for predicting the outcome of RMPP was 0.915, with a sensitivity of 88.9% and a specificity of 86.7% (P < 0.05). Conclusion The combination of LUS, CPIS, and serum inflammatory markers can effectively predict the timing of BAL intervention and the outcome of RMPP in children with MPP, which is sensitive, non-invasive, and precise, and is worthy of clinical promotion.
- Mycoplasma pneumoniae pneumonia,
- Lung ultrasound score,
- Clinical pulmonary infection score,
- Serum inflammatory markers,
- Children,
- ROC curve

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References(20)

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Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children

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Value of combined lung ultrasound, CPIS, and inflammatory markers for predicting the timing of lbronchoalveolar avage intervention and outcomes of refractory Mycoplasma pneumoniae pneumonia in children

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