Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 712-715
HUANG Yue, QIAN Luxin, XU Congying, YAO Lin, LI Yasong. Two cases of spondyloarthritis with dual HLA-B*27 subtype positivity and literature review[J]. Chinese Journal of General Practice, 2026, 24(4): 712-715. doi: 10.16766/j.cnki.issn.1674-4152.004474
Citation: HUANG Yue, QIAN Luxin, XU Congying, YAO Lin, LI Yasong. Two cases of spondyloarthritis with dual HLA-B*27 subtype positivity and literature review[J]. Chinese Journal of General Practice, 2026, 24(4): 712-715. doi: 10.16766/j.cnki.issn.1674-4152.004474
shu

Two cases of spondyloarthritis with dual HLA-B*27 subtype positivity and literature review

doi: 10.16766/j.cnki.issn.1674-4152.004474
  • 1.

    Department of Rheumatology and Immunology, Zhejiang Provincial People's Hospital/Hangzhou Medical College Affiliated People's Hospital, Hangzhou 310014, China

Funds:

 GZY-ZJ-KJ-23047

  • Received Date: 2025-10-26
    Abstract
  • HLA-B*27 dual positivity is a rare genetic phenotype in spondyloarthritis and may be associated with specific clinical manifestations and disease severity. This paper reports two cases of spondyloarthritis with dual positivity for HLA-B*2704 and HLA-B*2705, as well as for HLA-B*2704 and HLA-B*2702. Combined with a literature review, the following characteristics of spondyloarthritis with dual HLA-B*27 subtype positivity are summarized: (1) Dual positivity of HLA-B*27 subtypes is based on HLA-B*2704, most commonly presenting as simultaneous positivity for HLA-B*2704 and HLA-B*2705; the protective subtype HLA-B*2706 does not appear to exert a protective effects. (2) Most patients are male, with axial spondyloarthritis as the predominant clinical phenotype. (3) The patients show a poor response to nonsteroidal anti-inflammatory drugs demonstrate a favorable response to TNF-α inhibitors.

     

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