Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 646-649
CHEN Mingfei, CHEN Zongcun. Department of Endocrinology, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China[J]. Chinese Journal of General Practice, 2026, 24(4): 646-649. doi: 10.16766/j.cnki.issn.1674-4152.004460
Citation: CHEN Mingfei, CHEN Zongcun. Department of Endocrinology, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China[J]. Chinese Journal of General Practice, 2026, 24(4): 646-649. doi: 10.16766/j.cnki.issn.1674-4152.004460
shu

Department of Endocrinology, the Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China

doi: 10.16766/j.cnki.issn.1674-4152.004460

  • Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China

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 WSJK2024MS200

  • Received Date: 2025-03-22
    Available Online: 2026-08-31
    Abstract
  • Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes, often leading to pain, sensory abnormalities, and loss of function, which seriously affects the quality of life of patients. With the continuous increase in the global prevalence of diabetes, the prevention and control situation of DPN is severe, and research on its mechanism has attracted much attention. In recent years, novel adipokines such as Apelin, adiponectin, lipocalin-2, omentin-1, and Nesfatin-1, as bioactive molecules secreted by adipose tissue and potential biomarkers, have been extensively explored for their roles in metabolic diseases. Studies have shown that changes in the expression levels of these novel adipokines and their signaling pathways are closely related to the occurrence and development of DPN, and they may participate in the process of DPN through multiple mechanisms such as metabolic abnormalities, inflammatory responses, and nerve damage. However, current research on the specific mechanisms and clinical applications of novel adipokines in DPN is still insufficient. This article aims to summarize the mechanisms of action, influencing factors, and the latest research progress of these adipokines in DPN, explore the value of novel adipokines in the early diagnosis and intervention of DPN, and provide a theoretical basis and clinical reference for future research.

     

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