Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 630-632
WANG Linping, SHI Yongcun, ZHANG Hengfang, LI Na, LI Lijuan. Correlation between serum hs-CRP, five thyroid function parameters, and the severity of depression[J]. Chinese Journal of General Practice, 2026, 24(4): 630-632. doi: 10.16766/j.cnki.issn.1674-4152.004456
Citation: WANG Linping, SHI Yongcun, ZHANG Hengfang, LI Na, LI Lijuan. Correlation between serum hs-CRP, five thyroid function parameters, and the severity of depression[J]. Chinese Journal of General Practice, 2026, 24(4): 630-632. doi: 10.16766/j.cnki.issn.1674-4152.004456
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Correlation between serum hs-CRP, five thyroid function parameters, and the severity of depression

doi: 10.16766/j.cnki.issn.1674-4152.004456
  • 1.

    Department of Psychiatry, Heze Third People ' s Hospital, Heze, Shandong 274000, China

Funds:

 20210464

  • Received Date: 2025-10-11
    Abstract
  •   Objective  To explore the distribution differences of serum hypersensitive C-reactive protein (hs-CRP) and five thyroid function parameters in depression patients with different severity, in order to provide potential indicators for evaluating the condition of the disease.  Methods  A total of 114 patients with depression admitted to the Third People ' s Hospital of Heze City, the First Hospital of Hebei Medical University from January 2021 to December 2023 were enrolled and categorized into the mild group (48 cases), the moderate group (40 cases) and the severe group (26 cases) according to Hamilton depression scale (HAMD) score. The levels of serum hs-CRP, five thyroid function parameters and the relationship of each index with HAMD score were compared.  Results  Serum hs-CRP, TSH levels and HAMD scores in the mild group [(3.65±0.71) mg/L, (1.35±0.16) μIU/mL, (12.41±3.08) points] were lower than those in the moderate group [(7.63±1.59) mg/L, (1.81±0.30) μIU/mL, (20.55±2.31) points] and the severe group [(9.84±2.15) mg / L, (2.74±0. 58) μIU / mL, (28.39±2.02) points], meanwhile the moderate group was lower than the severe group (P < 0.05). Serum FT3 and FT4 levels in the mild group were higher than those in other two groups, and the moderate group was higher than the severe group (P < 0.05). Pearson correlation analysis showed that serum hs-CRP, TSH and HAMD scores were positively correlated, while serum FT3, FT4 and HAMD scores were negatively correlated (r=0.652, 0.560, -0.431, -0.464, P < 0.05).  Conclusion  Serum hs-CRP, TSH, FT3 and FT4 are closely related to the severity of depression, and may be an important auxiliary indicator for the assessment of the condition of patients with depression.

     

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