Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 610-612
WU Wei, HAO Shuli, MEI Yanjie, SHI Fangfang, LI Xinjie. The effect of GLP-1RA semaglutide on cognitive function and serum Aβ1-42 levels in patients with type 2 diabetes[J]. Chinese Journal of General Practice, 2026, 24(4): 610-612. doi: 10.16766/j.cnki.issn.1674-4152.004451
Citation: WU Wei, HAO Shuli, MEI Yanjie, SHI Fangfang, LI Xinjie. The effect of GLP-1RA semaglutide on cognitive function and serum Aβ1-42 levels in patients with type 2 diabetes[J]. Chinese Journal of General Practice, 2026, 24(4): 610-612. doi: 10.16766/j.cnki.issn.1674-4152.004451
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The effect of GLP-1RA semaglutide on cognitive function and serum Aβ1-42 levels in patients with type 2 diabetes

doi: 10.16766/j.cnki.issn.1674-4152.004451
  • 1.

    Department of Endocrinology, Bozhou People's Hospital Affiliated to Anhui Medical University, Bozhou, Anhui 236800, China

Funds:

 AHWJ2022b117

  • Received Date: 2025-08-12
    Abstract
  •   Objective  This study explores the effects of the glucagon-like peptide-1 receptor agonist semaglutide on the MoCA cognitive score and serum β-amyloid protein 1-42 (Aβ1-42) levels in patients with type 2 diabetes, aiming to provide a new therapeutic approach for improving the cognitive function of patients with type 2 diabetes.  Methods  Sixty patients with type 2 diabetes mellitus admitted to the Endocrinology Department of Bozhou People ' s Hospital from December 2022 to December 2023 were selected as the research subjects and randomly divided into two groups by random number method, with 30 cases in each group. The conventional group was treated with oral hypoglycemic drugs and/or insulin, while the semaglutide group was treated with semaglutide combined with oral hypoglycemic drugs and/or insulin. The treatment period was 6 months. The MoCA cognitive function scores and serum Aβ1-42 levels of the two groups after treatment were compared.  Results  There were no statistically significant differences in fasting blood glucose (FBG), glycosylated hemoglobin ratio (HbA1c%), triglycerides (TG), total cholesterol (TC), and insulin resistance index (HOMA-IR) between the two groups after treatment (P>0.05). The MoCA cognitive score of the semaglutide group [28.00 (26.00, 29.00) points] was higher than that of the control group [24.50 (23.00, 26.00) points, P < 0.001], and the serum Aβ1-42 level [(100.67±23.34) pg/mL] was lower than that of the control group [(119.03±34.43) pg/mL, P < 0.001].  Conclusion  Semaglutide can reduce the serum Aβ1-42 level in patients with type 2 diabetes, increase the MoCA cognitive score, and improve cognitive function.

     

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    • References(16)
  • [1]
    ŞEN G A, TANRIKULU S, BEŞER B, et al. Effects of prediabetes and type 2 diabetes on cognitive functions[J]. Endocrine, 2024, 85(1): 190-195.
    [2]
    ZHOU X Y, YING C J, HU B, et al. Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of c-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly[J]. Aging Cell, 2022, Feb; 21(2): e13543. DOI: 10.1111/acel.13543.
    [3]
    DENG S, HE R, YUE Z, et al. Association of advanced glycation end products with cognitive function: healthy dance study[J]. J Alzheimers Dis, 2024, 100(2): 551-562. doi: 10.3233/JAD-240296
    [4]
    JIANG L, YUAN N, ZHAO N, et al. Advanced glycation end products induce Aβ1-42 deposition and cognitive decline through H19/miR-15b/BACE1 axis in diabetic encephalopathy[J]. Brain Res Bull, 2022, 188: 187-196. doi: 10.1016/j.brainresbull.2022.08.007
    [5]
    CHENG H, ZHANG Z, ZHANG B, et al. Enhancement of impaired olfactory neural activation and cognitive capacity by liraglutide, but not dapagliflozin or acarbose, in patients with type 2 diabetes: a 16-week randomized parallel comparative study[J]. Diabetes Care, 2022, 45(5): 1201-1210. doi: 10.2337/dc21-2064
    [6]
    王林, 惠灿灿, 贾同贞, 等. GLP-1类似物司美格鲁肽对糖尿病大鼠认知功能影响[J]. 安徽医专学报, 2023, 22(5): 83-85.

    WANG L, HUI C C, JIA T Z, et al. Effect of GLP-1 analog smeglutide on cognitive function in diabetes rats[J]. Journal of Anhui Health Vocational & Technical College, 2023, 22(5): 83-85.
    [7]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020)版[J]. 中华糖尿病杂志, 2021, 13(4): 315-409.

    Chinese Diabetes Society. Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition)[J]. Chinese Journal of Diabetes, 2021, 13(4): 315-409.
    [8]
    王蓓蓓, 徐冬梅, 蔡锋, 等. 2型糖尿病患者血清甲基乙二醛, 脑源性神经营养因子及胰高血糖素样肽-1水平变化与认知功能的关系[J]. 中华实验外科杂志, 2024, 41(5): 920-920.

    WANG B B, XU D M, CAI F, et al. Correlation between changes of serum MG, BDNF and GLP-1 levels and cognitive function in patients with type 2 diabetes mellitus[J]. Chinese Journal of Experimental Surgery, 2024, 41(5): 920-920.
    [9]
    李修英, 杨湘英, 吴清清, 等. 杭州市社区老年2型糖尿病患者认知衰弱相关因素分析[J]. 中华全科医学, 2022, 20(2): 274-277. doi: 10.16766/j.cnki.issn.1674-4152.001849

    LI X Y, YANG X Y, WU Q Q, et al. Analysis of related factors of cognitive decline in elderly patients with type 2 diabetes in Hangzhou community[J]. Chinese Journal of General Practice, 2022, 20(2): 274-277. doi: 10.16766/j.cnki.issn.1674-4152.001849
    [10]
    KIM M J, BRONAS U G, QUINN L, et al. Cognitive function and self-management behaviors in older adults with type 2 diabetes[J]. Nurs Res, 2023, 72(1): 38-48. doi: 10.1097/NNR.0000000000000624
    [11]
    SHIMODA M, KANEKO K, NAKAGAWA T, et al. Relationship between fasting blood glucose levels in middle age and cognitive function in later life: the Aichi Workers ' Cohort Study[J]. J Epidemiol, 2023, 33(2): 76-81. doi: 10.2188/jea.JE20210128
    [12]
    DING J C, SHI Q, QIAN T, et al. Correlation between long-term glycemic variability and cognitive function in middle-aged and elderly patients with type 2 diabetes mellitus: a retrospective study[J]. Peer J, 2023 11: e16698. DOI: 10.7717/peerj.16698.
    [13]
    杨晶晶, 黄婷, 路瑶. 2型糖尿病患者血清胰高血糖素样肽-1水平与认知功能障碍的相关性研究[J]. 中华保健医学杂志, 2023, 25(1): 62-65.

    YANG J J, HUANG T, LU Y. Correlation between serum glucagon-like peptide-1 level and cognitive dysfunction in patients with type 2 diabetes mellitus[J]. Chinese Journal of Health Care Medicine, 2023, 25(1): 62-65.
    [14]
    LONGO M, D MEO I, CARUSO P, et al. Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes[J]. Diabetes Res Clin Pract, 2023, 200: 110688. DOI: 10.1016/j.diabres.2023.110688.
    [15]
    许雪, 孔璐璐, 李伟. 血清Aβ1-42及P-tau-181与老年2型糖尿病轻度认知功能障碍的关系[J]. 重庆医学, 2021, 50(24): 4193-4199.

    XU X, KONG L L, LI W. Association of serum Aβ1-42, P-tau-181 and mild cognitive impairment in older adults with type 2 diabetes mellitus[J]. Chongqing Medicine, 2021, 50(24): 4193-4199.
    [16]
    牛兆霞, 赵玉洁, 李玲玲. 血清Aβ1-42, GLP-1与2型糖尿病患者认知功能障碍的相关性及其危险因素分析[J]. 临床和实验医学杂志, 2024, 23(1): 32-36.

    NIU Z X, ZHAO Y J, LI L L. Correlation of serum Aβ1-42 and GLP-1 with cognitive impairment in patients with type 2 diabetes mellitus and analysis of risk factors[J]. Journal of Clinical and Experimental Medicine, 2024, 23(1): 32-36.
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