Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 601-604
PANG Xiaojun, SUN Wei, WANG Junwei. The regulatory effects of Bacillus subtilis combined with mesalazine on intestinal microecology and inflammatory factors in patients with ulcerative colitis[J]. Chinese Journal of General Practice, 2026, 24(4): 601-604. doi: 10.16766/j.cnki.issn.1674-4152.004449
Citation: PANG Xiaojun, SUN Wei, WANG Junwei. The regulatory effects of Bacillus subtilis combined with mesalazine on intestinal microecology and inflammatory factors in patients with ulcerative colitis[J]. Chinese Journal of General Practice, 2026, 24(4): 601-604. doi: 10.16766/j.cnki.issn.1674-4152.004449
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The regulatory effects of Bacillus subtilis combined with mesalazine on intestinal microecology and inflammatory factors in patients with ulcerative colitis

doi: 10.16766/j.cnki.issn.1674-4152.004449
  • 1.

    Department of Gastroenterology, Tiantai People's Hospital of Zhejiang Province, Tiantai, Zhejiang 317200, China

Funds:

 2025ZX057

  • Received Date: 2025-11-24
    Abstract
  •   Objective  To investigate the effects of Bacillus subtilis combined with mesalazine on the gut microbiota and inflammatory factors in patients with ulcerative colitis (UC), and to provide references to support the development of optimized clinical treatment plan formulation.  Methods  A total of 210 UC patients admitted to the Department of Gastroenterology, Tianta County People ' s Hospital of Zhejiang Province from May 2020 to May 2025 were randomly divided into Group A (n=105) and Group B (n=105). Group A was treated with mesalazine, while Group B was treated with mesalazine combined with Bacillus Licheniformis live bacteria capsules. The clinical efficacy, number of intestinal flora colonies, intestinal mucosal permeability, inflammatory factors, and adverse reactions were compared between the two groups.  Results  The total effective rate in the Group B [90.48% (95/105)] was higher than that in the Group A [79.05% (83/105), χ2=5.309, P=0.021]. After treatment, the counts of Lactobacillus and Bifidobacterium in the Group B were higher than those in the Group A (P < 0.05), whereas the count of Escherichia coli in the Group B was lower than that in the Group A (P < 0.05). The levels of diamine oxidase (DAO) and endotoxin (ETX) in the Group B after treatment were lower than those in the Group A (P < 0.05). The levels of C-reactive protein (CRP) and interleukin-8 (IL-8) in the Group B after treatment were lower than those in the Group A (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).  Conclusion  The combination of Bacillus licheniformis live bacteria capsules and mesalazine in the treatment of UC can enhance efficacy by modulating the structure of intestinal microbiota, enhancing the integrity of intestinal mucosal barrier, and reducing the expression of inflammatory factors, while maintaining a favorable safety profile.

     

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