Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 596-600
GAO Jun, BIAN Zhe, ZHANG Saixue. Effects of Tiaoshen Xingnao acupuncture on oxidative stress, miR-34a and SIRT1 in patients with cognitive impairment after stroke[J]. Chinese Journal of General Practice, 2026, 24(4): 596-600. doi: 10.16766/j.cnki.issn.1674-4152.004448
Citation: GAO Jun, BIAN Zhe, ZHANG Saixue. Effects of Tiaoshen Xingnao acupuncture on oxidative stress, miR-34a and SIRT1 in patients with cognitive impairment after stroke[J]. Chinese Journal of General Practice, 2026, 24(4): 596-600. doi: 10.16766/j.cnki.issn.1674-4152.004448
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Effects of Tiaoshen Xingnao acupuncture on oxidative stress, miR-34a and SIRT1 in patients with cognitive impairment after stroke

doi: 10.16766/j.cnki.issn.1674-4152.004448
  • 1.

    Rehabilitation Department of North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, China

Funds:

 2023334

  • Received Date: 2025-01-08
    Abstract
  •   Objective  This study investigated the effects of Tiaoshen Xingnao acupuncture on patients with post-stroke cognitive impairment by observing and comparing the changes in inflammatory response, stress response, cognitive function, and the expression levels of miR-34a and SIRT1, with the aim of providing new ideas and approaches for clinical treatment.  Methods  Ninety patients with post-stroke cognitive impairment treated in the Affiliated Hospital of North China University of Science and Technology from March 2023 to September 2023 were enrolled. Using a block randomization method, they were randomly assigned at a 2:1 ratio to an observation group (60 cases, Tiaoshen Xingnao acupuncture + cognitive function training) and a control group (30 cases, cognitive function training) according to the treatment modalities. The inflammatory response indicators (IL-6, CRP), oxidative stress response (SOD, MDA), cognitive effects (MESSS), and effects on miR-34a, SIRT1 were compared between the two groups.  Results  After 4 weeks of treatment, MDA [(5.68±0.86) μmol/mL vs. (8.37±1.68) μmol/mL] and MESSS [(14.00±3.00) points vs. (18.00±4.00) points] in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05), whereas SOD [(126.35±12.37) U/mL vs. (82.38±10.49) U/mL] was higher than that in the control group, with a statistically significant difference (P < 0.05). After 4 weeks of treatment, IL-6 [(148.59±29.67) pg/L vs. (209.59±26.37) pg/L] and CRP [(6.19±1.86) mg/L vs. (10.68±3.67) mg/L] in the observation group were lower than those in the control group, and the difference was statistically significant (P < 0.05). After 4 weeks of treatment, miR-34a [(1.16±0.19)] was lower than that in the control group [(1.46±0.16)], while SIRT1 [(1.16±0.22) vs. (0.93±0.18)] was higher than that in the control group, and the difference was statistically significant (P < 0.05).  Conclusion  Tiaoshen Xingnao acupuncture can improve oxidative stress responses, reduce inflammatory reactions, decrease the expression of miR-34a and SIRT1, and promote the recovery of cognitive function in patients with cognitive impairment after stroke.

     

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