Volume 24 Issue 4
Apr.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(4): 581-584
SUN Xing, FAN Baohan, CAI Yue, SHEN Tongtong. The relationship between lipoprotein lipase-related angiopoietin-like proteins and trimethyl-5-aminopentanoic acid with the severity of coronary artery stenosis[J]. Chinese Journal of General Practice, 2026, 24(4): 581-584. doi: 10.16766/j.cnki.issn.1674-4152.004444
Citation: SUN Xing, FAN Baohan, CAI Yue, SHEN Tongtong. The relationship between lipoprotein lipase-related angiopoietin-like proteins and trimethyl-5-aminopentanoic acid with the severity of coronary artery stenosis[J]. Chinese Journal of General Practice, 2026, 24(4): 581-584. doi: 10.16766/j.cnki.issn.1674-4152.004444
shu

The relationship between lipoprotein lipase-related angiopoietin-like proteins and trimethyl-5-aminopentanoic acid with the severity of coronary artery stenosis

doi: 10.16766/j.cnki.issn.1674-4152.004444

  • Department of Cardiovascular Medicine, the Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, Anhui 239001, China

Funds:

 AHWJ2024BAi30008

 2022xkj078

  • Received Date: 2025-11-13
    Abstract
  •   Objective  To investigate the correlation between angiopoietin-like proteins (ANGPTLs) related to lipoprotein lipase (LPL) and trimethyl-5-aminovaleric acid (TMAVA) with the severity of coronary artery stenosis, thereby providing a novel theoretical basis for the prediction, diagnosis, and treatment of coronary heart disease.  Methods  A total of 270 patients who underwent coronary angiography at the Affiliated Chuzhou Hospital of Anhui Medical University from June 2024 to June 2025 were consecutively enrolled. Gensini scores were calculated, and patients were divided into a high-score group (GS score > 15.6, 110 cases) and a non-high-score group (GS score ≤ 15.6, 160 cases). Subsequently, the non-high-score group was further categorized into a low-score group (0 < GS score ≤ 15.6, 49 cases) and a normal group (GS score = 0, 111 cases). Baseline data of the high-score, low-score, and normal groups were compared. Spearman correlation analysis was employed to explore the correlation between ANGPTLs (angiopoietin-like proteins) and TMAVA (trimethyl-5-aminovaleric acid) with the GS (Gensini) score. Logistic regression analysis was conducted to identify independent influencing factors for the occurrence of coronary heart disease.  Results  There were statistically significant differences in the history of diabetes, age, fasting plasma glucose (FPG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and non-high-density lipoprotein cholesterol (Non-HDL-C) among the high-score, low-score, and normal groups (all P < 0.05). Spearman correlation analysis revealed that ANGPTL3, ANGPTL4, ANGPTL8, and TMAVA were all positively correlated with the GS (Gensini) score (rs=0.754, 0.348, 0.749, 0.762, all P < 0.001). Logistic regression analysis indicated that elevated concentrations of ANGPTL3, ANGPTL4, ANGPTL8, and TMAVA were all independent risk factors for coronary heart disease [OR(95% CI)=1.614(1.435-1.864), 1.375(1.261-1.512), 14.488(6.643-36.374), 1.114(1.079-1.148), all P < 0.001].  Conclusion  LPL-associated ANGPTLs and TMAVA can serve not only as indicators for evaluating the severity of coronary artery lesions but also as potential markers for early identification of patients with coronary heart disease.

     

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    • References(19)
  • [1]
    张兰兰, 黄海珅, 李俊超, 等. CT血管成像对冠心病患者斑块状态、管腔狭窄的评估效果及临床应用价值[J]. 中华全科医学, 2024, 22(4): 551-554.

    ZHANG L L, HUANG H K, LI J C, et al. Evaluation effect and clinical application value of CT angiography on plaque status and luminal stenosis in patients with coronary heart disease[J]. Chinese Journal of General Practice, 2024, 22(4): 551-554.
    [2]
    国家心血管病中心, 中国心血管健康与疾病报告编写组, 胡盛寿. 中国心血管健康与疾病报告2024概要[J]. 中国循环杂志, 2025, 40(6): 521-559.

    National Center for Cardiovascular Diseases, The Writing Committee of the Report on Cardiovascular Health and Diseases in China, HU Shengshou. Report on Cardiovascular Health and Diseases in China 2024: an Updated Summary[J]. Chinese Circulation Journal, 2025, 40(6): 521-559.
    [3]
    ZHEN E Y, CHEN Y Q, RUSSELL A M, et al. Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity[J] Proc Natl Acad Sci U S A, 2023, 120(7): e2214081120. DOI: 10.1073/pnas.2214081120.
    [4]
    HAIKONEN R, KARKKAINEN O, KOISTINEN V, et al. Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease[J]. Trends Endocrinol Metab, 2022, 33(7): 463-480. doi: 10.1016/j.tem.2022.04.004
    [5]
    ZHAO M, WEI H, LI C, et al. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy[J]. Nat Commun, 2022, 13(1): 1757. DOI: 10.1038/s41467-022-29060-7.
    [6]
    曾小娟, 亚晓, 何新雨, 等. 残粒胆固醇的代谢过程、致动脉粥样硬化机制及其相关靶向生物制剂应用研究进展[J]. 山东医药, 2022, 62(29): 99-102.

    ZENG X J, YA X, HE X Y, et al. Research progress on the metabolic process, atherogenic mechanism of remnant cholesterol and the application of its related targeted biologics[J]. Shandong Medical Journal, 2022, 62(29): 99-102.
    [7]
    于猛, 孙维, 刘明新, 等. 残余胆固醇和TG/HDL-C与慢性冠脉综合征患者冠状动脉病变程度及短期预后的相关性[J]. 国际心血管病杂志, 2025, 52(2): 123-128.

    YU M, SUN W, LIU M X, et al. Association of residual cholesterol and TG/HDL-C with coronary disease severity and short-term prognosis in patients with chronic coronary syndrome[J]. International Journal of Cardiovascular Disease, 2025, 52(2): 123-128.
    [8]
    赵树媛, 王爽, 侯鹏, 等. 血清VASP、ANGPTL4联合血管内超声在冠心病患者冠状动脉斑块易损性评价中的价值研究[J]. 成都医学院学报, 2024, 19(5): 823-826, 831.

    ZHAO S Y, WANG S, HOU P, et al. Value of Serum VASP and ANGPTL4 Combined with Intravascular Ultrasound in the Prediction of Coronary Plaque Vulnerability in Patients with Coronary Heart Disease[J]. Journal of Chengdu Medical College, 2024, 19(5): 823-826, 831.
    [9]
    LANDFORS F, CHORELL E, KERSTEN S. Genetic mimicry analysis reveals the specific lipases targeted by the ANGPTL3-ANGPTL8 complex and ANGPTL4[J]. J Lipid Res, 2023, 64(1): 100313. DOI: 10.1016/j.jlr.2022.100313.
    [10]
    LI Y, LUO X, HUA Z, et al. Apolipoproteins as potential communicators play an essential role in the pathogenesis and treatment of early atherosclerosis[J]. Int J Biol Sci, 2023, 19(14): 4493-4510. doi: 10.7150/ijbs.86475
    [11]
    MUNNO M, MALLIA A, GRECO A, et al. Radical oxygen species, oxidized low-density lipoproteins, and lectin-like oxidized low-density lipoprotein receptor 1: a vicious circle in atherosclerotic process[J]. Antioxidants (Basel), 2024, 13(5): 583. DOI: 10.3390/antiox13050583.
    [12]
    SONG W, BEIGNEUX A P, WESTON T A, et al. The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing[J]. Proc Natl Acad Sci U S A, 2023, 120(44): e2313825120. DOI: 10.1073/pnas.2313825120.
    [13]
    BURKS K H, BASU D, GOLDBERG I J, et al. Angiopoietin-like 3: an important protein in regulating lipoprotein levels[J]. Best Pract Res Clin Endocrinol Metab, 2023, 37(3): 101688. DOI: 10.1016/j.beem.2022.101688.
    [14]
    ZHAO Z, DENG X, JIA J, et al. Angiopoietin-like protein 8(betatrophin) inhibits hepatic gluconeogenesis through PI3K/Akt signaling pathway in diabetic mice[J]. Metabolism, 2022, 126: 154921. DOI: 10.1016/j.metabol.2021.154921.
    [15]
    ZHANG Y, LIU X, ZENG L, et al. Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment[J]. Br J Cancer, 2022, 127(10): 1760-1772. doi: 10.1038/s41416-022-01956-7
    [16]
    HEMMATI M, KASHANIPOOR S, MAZAHERI P, et al. Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)[J]. Life Sci, 2023, 329: 121947. DOI: 10.1016/j.lfs.2023.121947.
    [17]
    LEANDER K, CHEN Y Q, VIKSTROM M, et al. Circulating ANGPTL3/8 concentrations are associated with an atherogenic lipoprotein profile and increased CHD risk in swedish population-based studies[J]. Arterioscler Thromb Vasc Biol, 2025, 45(3): 443-451. doi: 10.1161/ATVBAHA.124.321308
    [18]
    杨晓明, 郑祥, 王超超. 肠道菌群代谢产物与冠心病合并慢性心力衰竭的相关性及对患者预后水平的预测作用[J]. 中华全科医学, 2023, 21(10): 1676-1678, 1718.

    YANG X M, ZHENG X, WANG C C. Correlation between gut microbiota metabolites and coronary heart disease combined with chronic heart failure and its predictive role in patient prognosis[J]. Chinese Journal of General Practice, 2023, 21(10): 1676-1678, 1718.
    [19]
    SILBERNAGEL G, HIGBIE H, MEININGER T, et al. Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events[J]. Atherosclerosis, 2025, 409: 120485. DOI: 10.1016/j.atherosclerosis.2025.120485.
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