Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 521-524
MENG Siyu, CHEN Xiumin. A two-sample Mendelian randomized study of type 2 diabetes versus ankle fracture risk[J]. Chinese Journal of General Practice, 2026, 24(3): 521-524. doi: 10.16766/j.cnki.issn.1674-4152.004433
Citation: MENG Siyu, CHEN Xiumin. A two-sample Mendelian randomized study of type 2 diabetes versus ankle fracture risk[J]. Chinese Journal of General Practice, 2026, 24(3): 521-524. doi: 10.16766/j.cnki.issn.1674-4152.004433
shu

A two-sample Mendelian randomized study of type 2 diabetes versus ankle fracture risk

doi: 10.16766/j.cnki.issn.1674-4152.004433
  • 1.

    College of Orthopedics and Traumatology, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450046, China

Funds:

 2022ZY1192

 2024ZY2193

  • Received Date: 2025-02-11
    Available Online: 2026-06-02
    Abstract
  •   Objective  It has been proven that diabetes mellitus plays an important role in the occurrence and development of joint fractures. In this study, a two-sample Mendelian randomization analysis was conducted to investigate the causal relationship between diabetes and ankle fractures.  Methods  Data from published genome-wide association studies (GWAS) were collected, and 116 single-nucleotide polymorphisms (SNPs) were selected as instrumental variable (IVs) by removing linkage disequilibrium and confounding factors, setting correlation thresholds. The association between diabetes mellitus and the risk of ankle fracture was evaluated by inverse variance-weighted (IVW), MR-Egger, weighted median (WME), simple multivariate analysis (SM), and weighted multivariate analysis (WM). The sensitivity analysis was carried out by using the leave-one-out method, and the robustness of the results was evaluated by sensitivity analysis. The reliability and robustness of the MR analysis results were further evaluated by visual means. Cochran's Q test was used to detect heterogeneity between instrument variables.  Results  Statistical analysis showed that there was a significant causal relationship between diabetes mellitus and ankle fracture (IVW: OR=1.001, 95% CI: 1.001-1.002, P=0.035). The results of MR analysis showed that MR Egger (P=0.007), weighted median method (P=0.006), the results of the weighted model method (P=0.002) further verified this finding, the causal relationship obtained by the above methods was in the same direction, and the analysis of the leave-one-out method did not find a single SNP that significantly affected the overall results, and the heterogeneity test and pleiotropic experimental results supported the reliability and robustness of the MR conclusions.  Conclusion  There is a positive causal relationship between diabetes and ankle fractures, and diabetes is associated with an increased risk of ankle fractures.

     

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    • References(22)
  • [1]
    CARTER T H, OLIVER W M, BELL K R, et al. Operative vs nonoperative management of unstable medial malleolus fractures: a randomized clinical trial[J]. JAMA Netw Open, 2024, 7(1): e2351308. DOI: 10.1001/jamanetworkopen.2023.51308.
    [2]
    焦璇, 刘艳红, 李玲. 动态血糖监测联合胰岛素泵对2型糖尿病合并手外伤病人术后转归影响[J]. 青岛大学学报(医学版), 2024, 60(3): 433-435.

    JIAO X, LIU Y H, LI L. Effect of dynamic blood glucose monitoring combined with insulin pump on the postoperative outcome of patients with type 2 diabetes and hand injury[J]. Journal of Qingdao University(Medical Sciences), 2024, 60(3): 433-435.
    [3]
    PIGEYRE M, GERSTEIN H, AHLQVIST E, et al. Identifying blood biomarkers for type 2 diabetes subtyping: a report from the ORIGIN trial[J]. Diabetologia, 2023, 66(6): 1045-1051. doi: 10.1007/s00125-023-05887-7
    [4]
    刘瑜婷, 石敏, 陈燕娜, 等. 血清C1q/肿瘤坏死因子相关蛋白9水平与妊娠期糖尿病及其胰岛素抵抗的关系[J]. 中华全科医学, 2024, 22(2): 195-197, 229. doi: 10.16766/j.cnki.issn.1674-4152.003363

    LIU Y T, SHI M, CHEN Y N, et al. Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2024, 22(2): 195-197, 229. doi: 10.16766/j.cnki.issn.1674-4152.003363
    [5]
    谢艳华, 邱明俊, 张云. 分阶段个体化护理管理对老年糖尿病患者踝关节骨折术后治疗效果的影响[J]. 当代护士(下旬刊), 2023, 30(2): 84-87.

    XIE Y H, QIU M J, ZHANG Y. To explore the effect of staged and individualized nursing management on postoperative treatment of ankle fracture in elderly diabetic patients[J]. Modern Nurse, 2023, 30(2): 84-87.
    [6]
    高鹏, 邵晋康. 2型糖尿病骨折风险评价的研究进展[J]. 中国实用内科杂志, 2023, 43(5): 424-429.

    GAO P, SHAO J K. Research progress of fracture risk assessment in type 2 diabetes mellitus[J]. Chinese Journal of Practical Internal Medicine, 2023, 43(5): 424-429.
    [7]
    张俏, 周学志, 陈炳合, 等. 2型糖尿病与结直肠癌发生风险的两样本孟德尔随机化研究[J]. 中华全科医学, 2024, 22(9): 1471-1474, 1570. doi: 10.16766/j.cnki.issn.1674-4152.003661

    ZHANG Q, ZHOU X Z, CHEN B H, et al. A two sample Mendelian randomization study of type 2 diabetes mellitus and colorectal cancer risk[J]. Chinese Journal of General Practice, 2024, 22(9): 1471-1474, 1570. doi: 10.16766/j.cnki.issn.1674-4152.003661
    [8]
    XING X, WANG Y N, PAN F M, et al. Osteoarthritis and risk of type 2 diabetes: a two-sample Mendelian randomization analysis[J]. Diabetes, 2023, 15(11): 987-993. doi: 10.1111/1753-0407.13451
    [9]
    HO J, MAK C C H, SHARMA V, et al. Mendelian randomization studies of lifestyle-related risk factors for osteoarthritis: a PRISMA review and meta-analysis[J]. Int J Mol Sci, 2022, 23(19): 11906. DOI: 10.3390/ijms231911906.
    [10]
    CARTER A R, SANDERSON E, HAMMERTON G, et al. Mendelian randomisation for mediation analysis: current methods and challenges for implementation[J]. Eur J Epidemiol, 2021, 36(5): 465-478. doi: 10.1007/s10654-021-00757-1
    [11]
    CHEN L L, YANG H Q, LI H T, et al. Insights into modifiable risk factors of cholelithiasis: a Mendelian randomization study[J]. Hepatology, 2022, 75(4): 785-796. doi: 10.1002/hep.32183
    [12]
    LIN Z T, PAN I, PAN W. A practical problem with Egger regression in Mendelian randomization[J]. PLoS Genet, 2022, 18(5): e1010166. DOI: 10.1371/journal.pgen.1010166.
    [13]
    WANG X Q, WANG X L, WANG H K, et al. Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses[J]. BMC Pulm Med, 2023, 23(1): 4. DOI: 10.1186/s12890-022-02297-0.
    [14]
    LUO G, YAO Y Y, TAO J C, et al. Causal association of sleep disturbances and low back pain: a bidirectional two-sample Mendelian randomization study[J]. Front Neurosci, 2022, 16: 1074605. DOI: 10.3389/fnins.2022.1074605.
    [15]
    XU J W, ZHANG S Y, TIAN Y, et al. Genetic causal association between iron status and osteoarthritis: a two-sample mendelian randomization[J]. Nutrients, 2022, 14(18): 3683. DOI: 10.3390/nu14183683.
    [16]
    HUANG G W, CHEN X, CHEN Y B, et al. Causal relationship between type 2 diabetes mellitus and bone mineral density: a Mendelian randomization study in an East Asian population[J]. Osteoporos Int, 2023, 34(10): 1719-1727. doi: 10.1007/s00198-023-06807-6
    [17]
    LEANZA G, CANNATA F, FARAJ M, et al. Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength[J]. Elife, 2024, 12: RP90437. DOI: 10.7554/eLife.90437.
    [18]
    KHALID M, PETROIANU G, ADEM A. Advanced glycation end products and diabetes mellitus: mechanisms and perspectives[J]. Biomolecules, 2022, 2(4): 542. DOI: 10.3390/biom12040542.
    [19]
    AXELSSON K F, LITSNE H, KOUSOULA K, et al. Risk of fracture in adults with type 2 diabetes in Sweden: a national cohort study[J]. PLoS Med, 2023, 20(1): e1004172. DOI: 10.1371/journal.pmed.1004172.
    [20]
    SCHOUSBOE J T, MORIN S N, KLINE G A, et al. Differential risk of fracture attributable to type 2 diabetes mellitus according to skeletal site[J]. Bone, 2022, 154: 116220. DOI: 10.1016/j.bone.2021.116220.
    [21]
    SARODNIK C, RASMUSSEN N H, BOURS S P G, et al. The incidence of fractures at various sites in newly treated patients with type 2 diabetes mellitus[J]. Bone Rep, 2022, 17: 101614. DOI: 10.1016/j.bonr.2022.101614.
    [22]
    HAZELWOOD E, SANDERSON E, TAN V Y, et al. Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis[J]. BMC Med, 2022, 20(1): 125. DOI: 10.1186/s12916-022-02322-3.
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