Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression

HE Ting; CHEN Xiaohong; ZHONG Genlong; LAN Likang; LIU Minfen; WU Yu; LIU Huifen

doi:10.16766/j.cnki.issn.1674-4152.004420

Volume 24 Issue 3

Mar. 2026

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Article Navigation > Chinese Journal of General Practice > 2026 > 24(3): 464-467

HE Ting, CHEN Xiaohong, ZHONG Genlong, LAN Likang, LIU Minfen, WU Yu, LIU Huifen. Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression[J]. Chinese Journal of General Practice, 2026, 24(3): 464-467. doi: 10.16766/j.cnki.issn.1674-4152.004420

Citation:

HE Ting, CHEN Xiaohong, ZHONG Genlong, LAN Likang, LIU Minfen, WU Yu, LIU Huifen. Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression[J]. Chinese Journal of General Practice, 2026, 24(3): 464-467. doi: 10.16766/j.cnki.issn.1674-4152.004420

Citation:

HE Ting, CHEN Xiaohong, ZHONG Genlong, LAN Likang, LIU Minfen, WU Yu, LIU Huifen. Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression[J]. Chinese Journal of General Practice, 2026, 24(3): 464-467. doi: 10.16766/j.cnki.issn.1674-4152.004420

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Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression

doi: 10.16766/j.cnki.issn.1674-4152.004420

1.
Department of Neurology, Wenzhou Medical University Lishui Hospital, Lishui College Affiliated First Hospital, Lishui People ' s Hospital, Lishui, Zhejiang 323000, China

Funds:

2022KY1443

ZJDKF202101

Received Date: 2025-03-23
Available Online: 2026-06-02

Abstract

Abstract

Objective To investigate the repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavior therapy (CBT) on post-stroke depression (PSD). Methods Eighty patients diagnosed with post-stroke depression in our hospital from September 2022 to August 2023 were selected. They were divided into a control group and an observation group according to the random number table, with 40 cases in each group. During the research process, 5 cases dropped out. In the end, there were 37 cases in the observation group and 38 cases in the control group. The control group received conventional treatment, while the observation group was additionally treated with low-frequency repetitive transcranial magnetic stimulation (rTMS) and cognitive-behavioral therapy, and the treatment lasted for 8 weeks. Before treatment, at 4 weeks of treatment, and at 8 weeks of treatment, the self-rating depression scale (SDS), self-rating anxiety scale (SAS), mini-mental state examination (MMSE), Pittsburgh sleep quality index (PSQI), and National Institutes of Health stroke scale (NIHSS) were used to assess the emotional state, mental state, sleep condition, and neurological function rehabilitation of the two groups of patients. Results At 4 weeks and after 8 weeks of treatment, SDS, SAS, MMSE, PSQI, and NIHSS scores of patients in both groups were significantly improved (P < 0.001), and the observation group was better than the control group. After 4 weeks of treatment, MMSE and NIHSS in the observation group improved significantly compared with the control group [(24.67±1.33) points vs. (21.55±1.48) points, F=9.608, P < 0.001; (8.43±1.01) points vs. (9.15±0.97) points, F=3.147, P=0.002]. After 8 weeks of treatment, the SDS, SAS, MMSE, PSQI, and NIHSS in the observation group improved significantly compared with the control group (P < 0.001). Conclusion Repetitive transcranial magnetic stimulation combined with cognitive behavior therapy can effectively improve sleep quality, relieve depression in patients with post-stroke depression, and enhance cognitive behavior.
- Post-stroke depression,
- Repetitive transcranial magnetic stimulation,
- Cognitive behavioral therapy

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References(21)

References

[1]	李磊, 李锡泽, 何竟. 脑卒中后疲劳的研究现状分析[J], 中国康复, 2020, 35(6): 329-332. LI L, LI X Z, HE J. Analysis of the research status of post-stroke fatigue[J]. China Rehabilitation, 2020, 35(6): 329-332.
[2]	郝广志, 董玉书, 张冰莹, 等. 1990至2021年全球中年人群缺血性脑卒中发病趋势及年龄-时期-队列模型分析[J]. 中华神经外科疾病研究杂志, 2024, 18(6): 8-14. HAO G Z, DONG Y S, ZHANG B Y, et al. Global incidence trends of ischemic stroke in middle-aged population from 1990 to 2021 and age-period- cohort model analysis[J]. Chinese Journal of Neurosurgical Disease Research, 2024, 18(6): 8-14.
[3]	王健翔, 殷小焦, 高云. 基于网络药理学及分子对接探讨姜黄素治疗卒中后抑郁的作用机制[J]. 神经解剖学杂志, 2024, 40(4): 464-470. WANG J X, YIN X J, GAO Y. Exploration of the mechanism of curcumin in the treatment of post-stroke depression based on network pharmacology and molecular docking[J]. Chinese Journal of Neuroanatomy, 2024, 40(4): 464-470.
[4]	杨雪, 桑坤琳, 王玲玲. 缺血性脑卒中后抑郁相关危险因素[J]. 北华大学学报(自然科学版), 2024, 25(5): 638-642. YANG X, SANG K L, WANG L L. Related risk factors of post-ischemic stroke depression[J]. Journal of Beihua University (Natural Science Edition), 2024, 25(5): 638-642.
[5]	于足, 吴珍, 俞波, 等. 睡眠脑电图评价重复经颅磁刺激治疗脑卒中后抑郁的疗效[J]. 中华物理医学与康复杂志, 2024, 46(10): 907-910. YU Z, WU Z, YU B, et al. Evaluation of the efficacy of repetitive transcranial magnetic stimulation in the treatment of post-stroke depression by sleep electroencephalogram[J]. Chinese Journal of Physical Medicine and Rehabilitation, 2024, 46(10): 907-910.
[6]	中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. Chinese Society of Neurology, Chinese Society of Neurology, Chinese Society of Cerebrovascular Disease. Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018[J]. Chinese Journal of Neurology, 2018, 51(9): 666-682.
[7]	郑继青, 龙耀斌, 徐金. 辣椒素联合重复经颅磁刺激用于脑卒中后吞咽障碍患者的疗效观察[J]. 天津医药, 2024, 52(9): 950-953. ZHENG J Q, LONG Y B, XU J. Efficacy observation of capsaicin combined with repetitive transcranial magnetic stimulation in patients with post-stroke dysphagia[J]. Tianjin Medical Journal, 2024, 52(9): 950-953.
[8]	何萌, 来永强, 张喜维, 等. 心脏外科不同疾病患者合并睡眠障碍的状况及其相关因素[J]. 中华医学杂志, 2024, 104(40): 3745-3750. HE M, LAI Y Q, ZHANG X W, et al. Status and related factors of sleep disorders in patients with different cardiac surgical diseases[J]. National Medical Journal of China, 2024, 104(40): 3745-3750.
[9]	李袁豪, 吉洁. 作业疗法对老年脑卒中后抑郁伴轻度认知障碍患者精神状态及执行能力的疗效分析[J]. 老年医学与保健, 2024, 30(5): 1325-1328, 1337. LI Y H, JI J. Efficacy analysis of occupational therapy on mental state and executive ability in elderly patients with post-stroke depression and mild cognitive impairment[J]. Geriatrics & Health Care, 2024, 30(5): 1325-1328, 1337.
[10]	张金朋, 陈慧杰, 李保龙, 等. 头穴丛刺联合重复经颅磁刺激治疗脑卒中后焦虑障碍临床疗效观察[J]. 中医药学报, 2023, 51(4): 79-83. ZHANG J P, CHEN H J, LI B L, et al. Clinical efficacy observation of scalp-point cluster needling combined with repetitive transcranial magnetic stimulation in the treatment of post-stroke anxiety disorder[J]. Acta Chinese Medicine and Pharmacology, 2023, 51(4): 79-83.
[11]	吉莉, 周蓓, 吕翔, 等. 重复经颅磁刺激联合励-协夫曼言语治疗对脑卒中后吞咽障碍联合嗓音障碍患者嗓音质量的影响研究[J]. 实用心脑肺血管病杂志, 2024, 32(11): 120-124. JI L, ZHOU B, LYU X, et al. Study on the effect of repetitive transcranial magnetic stimulation combined with Lee-Silverman voice treatment on voice quality in patients with post-stroke dysphagia and voice disorder[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2024, 32(11): 120-124.
[12]	张琪雅, 邵浩月, 欧和曼, 等. 功能磁共振成像评价重复经颅磁刺激治疗脑卒中后功能障碍的研究进展[J]. 中华物理医学与康复杂志, 2024, 46(8): 760-763. ZHANG Q Y, SHAO H Y, OU H M, et al. Research progress of functional magnetic resonance imaging in evaluating the treatment of post-stroke dysfunction by repetitive transcranial magnetic stimulation[J]. Chinese Journal of Physical Medicine and Rehabilitation, 2024, 46(8): 760-763.
[13]	田慧军, 王翼, 杜娜, 等. 低频重复经颅磁刺激对缺血性脑卒中后失眠患者睡眠质量及HPA轴相关激素的影响[J]. 中华航海医学与高气压医学杂志, 2024, 31(4): 486-490. TIAN H J, WANG Y, DU N, et al. Effects of low-frequency repetitive transcranial magnetic stimulation on sleep quality and hypothalamic-pituitary-adrenal axis-related hormones in patients with insomnia after ischemic stroke[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2024, 31(4): 486-490.
[14]	梁玉, 李艳芳, 王小波. 逍遥散联合重复经颅磁刺激治疗肝郁脾虚型抑郁症疗效及对患者血清FGF-22、BDNF水平的影响[J]. 陕西中医, 2021, 42(1): 33-36. LIANG Y, LI Y F, WANG X B. Efficacy of Xiaoyao San combined with repetitive transcranial magnetic stimulation in the treatment of liver-depression and spleen-deficiency type depression and its influence on serum FGF-22 and BDNF levels in patients[J]. Shaanxi Journal of Traditional Chinese Medicine, 2021, 42(1): 33-36.
[15]	张桂荣, 张妍妍, 梁文斌, 等. 单侧颈内动脉闭塞患者脑灌注与症状、闭塞时期及闭塞位置的关系[J]. 分子影像学杂志, 2024, 47(7): 684-688. ZHANG G R, ZHANG Y Y, LIANG W B, et al. Relationship between cerebral perfusion and symptoms, occlusion period and occlusion location in patients with unilateral internal carotid artery occlusion[J]. Journal of Molecular Imaging, 2024, 47(7): 684-688.
[16]	宋海英, 刘艺, 高鹏举. 艾司西酞普兰联合rTMS对老年脑卒中后抑郁患者认知功能和负性情绪的影响[J]. 国际医药卫生导报, 2024, 30(21): 3531-3536. SONG H Y, LIU Y, GAO P J. Effects of escitalopram combined with rTMS on cognitive function and negative emotions in elderly patients with post-stroke depression[J]. International Medicine & Health Guidance News, 2024, 30(21): 3531-3536.
[17]	刘益彤, 严舒雅, 孙靖延, 等. 童年创伤影响社交焦虑障碍的心理与生物机制研究进展[J]. 中国神经精神疾病杂志, 2024, 50(9): 565-569. LIU Y T, YAN S Y, SUN J Y, et al. Research progress on the psychological and biological mechanisms of childhood trauma affecting social anxiety disorder[J]. Chinese Journal of Nervous and Mental Diseases, 2024, 50(9): 565-569.
[18]	丁少杰, 冯志杰, 王鑫, 等. 针刺与选择性五羟色胺再摄取抑制剂治疗脑卒中后抑郁疗效对比的Meta分析[J]. 浙江中西医结合杂志, 2024, 34(9): 853-859. DING S J, FENG Z J, WANG X, et al. Meta-analysis of the efficacy comparison between acupuncture and selective serotonin reuptake inhibitors in the treatment of post-stroke depression[J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2024, 34(9): 853-859.
[19]	董震, 张云淑, 吴涵, 等. 功能磁共振引导下的重复经颅磁刺激对抑郁症短期疗效和执行功能的影响[J]. 河北医药, 2022, 44(8): 1156-1159. DONG Z, ZHANG Y S, WU H, et al. Effects of functional magnetic resonance imaging-guided repetitive transcranial magnetic stimulation on short-term efficacy and executive function in depression[J]. Hebei Medical Journal, 2022, 44(8): 1156-1159.
[20]	魏鹏, 周楠, 刘家欢, 等. 柴胡类方联合选择性5-羟色胺再摄取抑制剂治疗卒中后抑郁疗效与安全性的Meta分析[J]. 新中医, 2023, 55(3): 34-40. WEI P, ZHOU N, LIU J H, et al. Meta-analysis of the efficacy and safety of Bupleurum-containing prescriptions combined with selective serotonin reuptake inhibitors in the treatment of post-stroke depression[J]. Journal of New Chinese Medicine, 2023, 55(3): 34-40.
[21]	张淑红, 凌迎春, 罗方, 等. 丁苯酞联合重复经颅磁刺激对脑梗死后轻度认知障碍的疗效观察[J]. 中华全科医学, 2024, 22(4): 618-621. doi: 10.16766/j.cnki.issn.1674-4152.003464 ZHANG S H, LING Y C, LUO F, et al. Observation of the therapeutic effect of butylphthalein combined with repetitive transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction[J]. Chinese Journal of General Practice, 2024, 22(4): 618-621. doi: 10.16766/j.cnki.issn.1674-4152.003464

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Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavior therapy on post-stroke depression

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