Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 429-432
YANG Jun, CHU Ruzai, CHEN Zhengbin, CHEN Ying, CHEN Congping. Progressive resistance training combined with neuromuscular exercise for the treatment of knee osteoarthritis and its impact on inflammatory factors[J]. Chinese Journal of General Practice, 2026, 24(3): 429-432. doi: 10.16766/j.cnki.issn.1674-4152.004412
Citation: YANG Jun, CHU Ruzai, CHEN Zhengbin, CHEN Ying, CHEN Congping. Progressive resistance training combined with neuromuscular exercise for the treatment of knee osteoarthritis and its impact on inflammatory factors[J]. Chinese Journal of General Practice, 2026, 24(3): 429-432. doi: 10.16766/j.cnki.issn.1674-4152.004412
shu

Progressive resistance training combined with neuromuscular exercise for the treatment of knee osteoarthritis and its impact on inflammatory factors

doi: 10.16766/j.cnki.issn.1674-4152.004412

  • Department of Orthopedics, Tiantai People's Hospital of Zhejiang Province, Taizhou, Zhejiang 317200, China

Funds:

 2025KY1908

  • Received Date: 2025-11-22
    Available Online: 2026-06-02
    Abstract
  •   Objective  In recent years, non-pharmacological treatments (such as exercise therapy) have become increasingly prominent in the management of knee osteoarthritis (KOA), but traditional single-mode rehabilitation interventions have therapeutic limitations. This study aims to explore the clinical efficacy of progressive resistance training (PRT) combined with neuromuscular exercise therapy (NEMEX) in patients with knee osteoarthritis (KOA) and its impact on inflammatory factors in knee synovial fluid.  Methods  A total of 110 patients with KOA admitted to the Department of Orthopedics, People's Hospital of Tiantai County from July 1, 2024 to July 1, 2025 were selected as the research subjects. The patients were randomly grouped, with 55 cases in each group. The control group was treated with NEMEX, while the observation group was treated with NEMEX+PRT for a total of eight weeks. The system collected the clinical data of the two groups of patients before treatment and eight weeks after treatment, mainly including the assessment of the degree of pain by the visual analogue scale (VAS) for pain. The knee osteoarthritis score scale (KOOS) and the knee joint function score (Lysholm) were used to assess the severity of the patient's condition. Knee joint range of motion (AROM) and 10-meter walk test (10MWT) were used to assess the patients' mobility. The levels of IL-17, IL-1β, and PGE2 in knee joint synovial fluid. The quality of life of patients was evaluated by using the Quality of Life Scale (QOL) and the Activity of Daily Living Scale (ADL).  Results  After treatment, the VAS score and 10MWT of the patients in the observation group were significantly lower than those in the control group [(2.52±0.71) points vs. (3.18±0.86) points; (10.37±1.27) s vs.(11.21±1.36) s, P < 0.05]. The scores of KOOS, Lysholm, AROM, QOL, and ADL in the observation group were higher than those in the control group (P < 0.05). After treatment, the levels of IL-17, IL-1β, and PGE2 in both groups decreased, and those in the observation group were lower than those in the control group during the same period (P < 0.05).  Conclusion  Progressive resistance training combined with neuromuscular exercise therapy has a good clinical application effect in patients with knee osteoarthritis. It can improve pain conditions, enhance the motor capacity of the knee joint, reduce the levels of inflammatory factors in the knee joint, and improve the living ability and quality of life of patients.

     

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    • References(24)
  • [1]
    姚乐, 王渊, 乔海法, 等. 针刀治疗膝骨性关节炎的价值[J]. 中国中医基础医学杂志, 2025, 31(12): 2249-2253.

    YAO L, WANG Y, QIAO H F, et al. Value of acupotomy in treating knee osteoarthritis[J]. Journal Of Basic Chinese Medicine, 2025, 31(12): 2249-2253.
    [2]
    DUDONIENĖ V, BITINAS D, ŽLIBINAITĖ L. Comparison of three different therapeutic interventions in the management of knee osteoarthritis: randomized controlled parallel group pilot trial[J]. Osteoarthr Cartil Open, 2025, 7(4): 100697. DOI: 10.1016/j.ocarto.2025.100697.
    [3]
    DING Y P, ZHANG Z D, JIA H G. A nomogram for predicting total knee arthroplasty after arthroscopy in knee osteoarthritis: the role of pain, inflammation, and sleep[J]. J Radiat Res Appl Sci, 2025, 18(4): 102055. DOI: 10.1016/j.jrras.2025.102055.
    [4]
    TAN Y W, CHEN Y N, LI H L. Assessing radial shock wave therapy in knee osteoarthritis using a morphology-based graph-cut algorithm on CT images[J]. J Radiat Res Appl Sci, 2025, 18(4): 102044. DOI: 10.1016/j.jrras.2025.102044.
    [5]
    廖婕, 吴琼瑶, 吴功华, 等. 1990—2023年中国膝骨关节炎疾病负担现状及趋势分析[J]. 中国修复重建外科杂志, 2025, 39(11): 1381-1387.

    LIAO J, WU Q Y, WU G H, et al. Analysis of current status and trends of disease burden of knee osteoarthritis in China, 1990—2023[J]. Chinese Journal of Reparative and Reconstructive Surgery, 2025, 39(11): 1381-1387.
    [6]
    MOHAMED S H P, ALBALAWI H F, NAMBI G, et al. Effectiveness of manual therapy vs conventional physical therapy with neuromuscular training in the management of knee osteoarthritis: a randomized clinical controlled trial[J]. Int J Osteopath Med, 2025, 58: 100787. DOI: 10.1016/j.ijosm.2025.100787.
    [7]
    樊志娇, 靳岚琦, 朱健豪, 等. 认知运动疗法位置觉训练对膝骨性关节炎术后患者本体感觉的临床疗效观察[J]. 北京医学, 2023, 45(12): 1053-1057.

    FAN Z J, JIN L Q, ZHU J H, et al. Clinical observation of the effect of position sense training of cognitive therapeutic exercise on proprioception in patients with knee osteoarthritis after operation[J]. Beijing Medical Journal, 2023, 45(12): 1053-1057.
    [8]
    LIU Y D, ZHAO W M, CHANG Y N, et al. Comparison of periarticular knee anatomy between patients with knee osteoarthritis and normal adults[J]. J Orthop, 2026, 71: 175-179. doi: 10.1016/j.jor.2025.08.054
    [9]
    姜涛, 苗佳宁, 王政, 等. 4周中等强度跑台运动对碘乙酸钠诱导的膝骨关节炎大鼠软骨病理特征及Cytl1-CCR2通路活性的影响[J]. 中国康复医学杂志, 2025, 40(8): 1137-1147.

    JIANG T, MIAO J N, WANG Z, et al. Effects of 4-week moderate intensity treadmill exercise on pathological characteristics and Cytl1-CCR2 pathway activity of knee cartilage in MIA-induced knee osteoarthritis rats[J]. Chinese Journal of Rehabilitation Medicine, 2025, 40(8): 1137-1147.
    [10]
    娄晓乐, 陶雅亭, 林霖, 等. 神经肌肉运动训练联合半导体激光对膝骨关节炎患者的影响[J]. 康复学报, 2025, 35(4): 439-444.

    LOU X L, TAO Y T, LIN L, et al. Effect of neuromuscular exercise training combined with semiconductor laser on patients with knee osteoarthritis[J]. Journal of Rehabilitation Medicine, 2025, 35(4): 439-444.
    [11]
    WANG X Y, JIANG W J, ZHENG Z C. A novel hypothesis on the pathogenesis of knee osteoarthritis: the muscle weakness-joint instability and stress overload-uneven bone settlement cascade[J]. Medical Hypotheses, 2025, 205: 111791. DOI: 10.1016/j.mehy.2025.111791.
    [12]
    段碧璇, 张宇璇, 马裴, 等. 运动恐惧对膝骨关节炎患者下肢肌肉激活的影响[J]. 医用生物力学, 2025, 40(3): 606-614.

    DUAN B X, ZHANG Y X, MA P, et al. Effects of Fear of Movement on Lower Limb Muscle Activation in Patients with Knee Osteoarthritis[J]. Journal of Medical Biomechanics, 2025, 40(3): 606-614.
    [13]
    王健, 李志军. 骨关节炎的诊断与治疗[J]. 中华全科医学, 2020, 18(3): 347-348. http://www.zhqkyx.net/article/id/3a39a47b-c02d-4940-890f-de96249c6c2d

    WANG J, LI Z J. Diagnosis and treatment of osteoarthritis[J]. Chinese Journal of General Practice, 2020, 18(3): 347-348. http://www.zhqkyx.net/article/id/3a39a47b-c02d-4940-890f-de96249c6c2d
    [14]
    夏翠宏, 邢菲, 李洋, 等. 中老年女性膝骨关节炎患者坐-站转换及上下台阶中膝周肌肉激活的观察性研究[J]. 中国康复医学杂志, 2025, 40(6): 909-916.

    XIA C H, XING F, LI Y, et al. An observational study on knee peri-muscle activation during sit-to-stand, stand-to-sit, and stair ascent/descent in middle-aged and elderly female patients with knee osteoarthritis[J]. Chinese Journal of Rehabilitation Medicine, 2025, 40(6): 909-916.
    [15]
    李锡, 任晓颖, 焦永伟, 等. 髋-膝-踝主、被动运动疗法对早、中期膝骨关节炎患者的疗效[J]. 实用医学杂志, 2025, 41(6): 829-837.

    LI X, REN X Y, JIAO Y W, et al. The effect of hip-knee-ankle active and passive movement therapy on joint function in early and intermedi-ate-stage knee osteoarthritis patients[J]. The Journal of Practical Medicine, 2025, 41(6): 829-837.
    [16]
    芦浩, 王鹏, 王智勇, 等. 单髁关节置换术与全膝关节置换术对内侧单间室膝骨关节炎患者围术期指标和膝关节功能和术后并发症的影响[J]. 河北医学, 2023, 29(2): 317-322.

    LU H, WANG P, WANG Z Y, et al. Effects of unicompartmental knee arthroplasty and total knee arthroplasty onperioperative indexes, knee function and postoperative complications inpatients with medial unicompartmental knee osteoarthritis[J]. Hebei Medicine, 2023, 29(2): 317-322.
    [17]
    刘龙呈, 张峰, 高鹏翼, 等. 从运动生物力学角度探讨太极拳改善膝骨关节炎的作用机制[J]. 康复学报, 2024, 34(4): 411-416.

    LIU L C, ZHANG F, GAO P Y, et al. Mechanism of Tai Chi Chuan in improving knee osteoarthritis from the perspective of sports biomechanics[J]. Rehabilitation Medicine, 2024, 34(4): 411-416.
    [18]
    潘登, 肖立美, 孙晓娜, 等. 立式八段锦运动处方治疗早期膝骨关节炎效果观察[J]. 山东医药, 2025, 65(8): 76-80, 84.

    PAN D, XIAO L M, SUN X N, et al. Efficacy observation of standing Baduanjin exercise prescription in the treatment of early-stage knee osteoarthritis[J]. Shandong Medical Journal, 2025, 65(8): 76-80, 84.
    [19]
    王彦艳, 姚梁怡, 蔡立柏, 等. 膝骨关节炎非手术治疗患者运动干预的最佳证据总结[J]. 护理学杂志, 2024, 39(8): 102-106.

    WANG Y Y, YAO L Y, CAI L B, et al. Summary of the best evidence regarding exercise intervention for patients receiving non-surgical treatment for knee osteoarthritis[J]. Journal of Nursing Science, 2024, 39(8): 102-106.
    [20]
    于长禾, 周彦吉, 安易, 等. 基于多阶段优化策略构建中医治疗膝骨关节炎的综合方案[J]. 中华中医药杂志, 2023, 38(7): 3383-3387.

    YU C H, ZHOU Y J, AN Y, et al. Constructing traditional Chinese medical treatment protocol for knee osteoarthritis based on multiphase optimization strategy[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2023, 38(7): 3383-3387.
    [21]
    马健文, 岳虹妤, 谢超群, 等. 传统功法干预膝骨关节炎的临床应用及效应机制研究进展[J]. 上海中医药杂志, 2023, 57(12): 96-100.

    MA J W, YUE H Y, XIE C Q, et al. Research progress on clinical application and effector mechanism of traditional Chinese exercises in knee osteoarthritis[J]. Shanghai Journal of Traditional Chinese Medicine, 2023, 57(12): 96-100.
    [22]
    张冠聪, 黄秋晨, 顾蕊, 等. 不同神经肌肉训练方法对早期膝骨关节炎患者疼痛和运动功能效果的比较[J]. 中国康复理论与实践, 2023, 29(9): 1090-1097.

    ZHANG G C, HUANG Q C, GU R, et al. Comparative effect of different neuromuscular exercises on pain and motor function of knee in patients with early knee osteoarthritis[J]. Chinese Journal of Rehabilitation Theory and Practice, 2023, 29(9): 1090-1097.
    [23]
    刘翔, 蒋晶晶, 连晓文, 等. 塞来昔布联合硫酸氨基葡萄糖氯化钾配合推拿手法治疗膝骨关节炎的效果及对关节功能与炎性指标的影响[J]. 临床合理用药, 2025, 18(31): 121-124.

    LIU X, JIANG J J, LIAN X W, et al. Efficacy of celecoxib combined with glucosamine sulfate potassium chloride and massage manipulation in the treatment of knee osteoarthritis and its effects on joint function and inflammatory markers[J]. Chinese Journal of Clinical Rational Drug Use, 2025, 18(31): 121-124.
    [24]
    李标, 赵行, 杨凯, 等. 短波疗法结合深层肌肉刺激仪对早期膝骨关节炎患者炎性因子及症状改善效果研究[J]. 医药论坛杂志, 2025, 46(7): 683-687.

    LI B, ZHAO H, YANG K, et al. Effect of short-wave therapy combined with deep muscle stimulator on inflammatory improving symptoms and factors in patients with early osteoarthritis knee[J]. Journal of Medical Forum, 2025, 46(7): 683-687.
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