Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 424-428
HUANG Yaqiong, ZHOU Fang, ZHU Weihong, ZOU Jing, CHEN Tiexia. Effect of multi-mode perception control and motion interactive rehabilitation on cancer related fatigue level of breast cancer patients undergoing chemotherapy[J]. Chinese Journal of General Practice, 2026, 24(3): 424-428. doi: 10.16766/j.cnki.issn.1674-4152.004411
Citation: HUANG Yaqiong, ZHOU Fang, ZHU Weihong, ZOU Jing, CHEN Tiexia. Effect of multi-mode perception control and motion interactive rehabilitation on cancer related fatigue level of breast cancer patients undergoing chemotherapy[J]. Chinese Journal of General Practice, 2026, 24(3): 424-428. doi: 10.16766/j.cnki.issn.1674-4152.004411
shu

Effect of multi-mode perception control and motion interactive rehabilitation on cancer related fatigue level of breast cancer patients undergoing chemotherapy

doi: 10.16766/j.cnki.issn.1674-4152.004411
  • 1.

    The Fourth Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China

Funds:

 2022PY079

  • Received Date: 2025-04-09
    Available Online: 2026-06-02
    Abstract
  •   Objective  This study aims to explore the intervention effect of exercise interactive rehabilitation system (MPCI-R) based on multimodal perceptual control technology on cancer-related fatigue (CRF) in breast cancer patients undergoing chemotherapy, and evaluate its effect on cellular immune function, in order to provide a more interactive and individualized rehabilitation program for clinical practice.  Methods  Seventy patients undergoing postoperative chemotherapy for breast cancer at Hangzhou First People's Hospital between January and December 2023 were randomly assigned to a control group (n=34) and an intervention group (n=35) using the random number table. The control group received conventional exercise rehabilitation and comprehensive CRF management. The intervention group also received an 8-week MPCI-R (≥5 sessions per week, ≥150 minutes cumulatively, aerobic and resistance training combined with wearable sensors and virtual reality feedback). The primary outcome was the piper fatigue scale-Chinese (RPFS-C) score at baseline, 4 weeks, and 8 weeks. Secondary outcomes were the percentages of CD3+, CD4+, CD8+ T cells, and natural killer (NK) cells in peripheral blood (baseline and 8 weeks).  Results  Baseline RPFS-C did not differ between groups (P>0.05). At 4 and 8 weeks after intervention, the RPFS-C of the intervention group was lower than that of the control group [(4.23±1.52) vs. (5.59±1.40), t=3.873, P < 0.001; (3.43±1.34) vs. (5.06±1.35), t=5.049, P < 0.001]. Repeated-measures ANOVA indicated significant main effects of group and time and a group×time interaction (P < 0.001). At week 8, the intervention group had higher CD3+ T cells, CD4+ T cells, and NK cell proportions and lower CD8+ T cells proportion than controls (P < 0.05).  Conclusion  Adding MPCI-R to usual care significantly reduces CRF and favorably modulates immune cell profiles during chemotherapy for breast cancer, supporting its feasibility and potential for broader implementation.

     

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