Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 420-423
HU Kunmiao, ZHOU Limin, YU Zhenhua. Analysis of the current status of Helicobacter pylori infection, antibiotic resistance, and associated factors in patients at a Grade B tertiary hospital[J]. Chinese Journal of General Practice, 2026, 24(3): 420-423. doi: 10.16766/j.cnki.issn.1674-4152.004410
Citation: HU Kunmiao, ZHOU Limin, YU Zhenhua. Analysis of the current status of Helicobacter pylori infection, antibiotic resistance, and associated factors in patients at a Grade B tertiary hospital[J]. Chinese Journal of General Practice, 2026, 24(3): 420-423. doi: 10.16766/j.cnki.issn.1674-4152.004410
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Analysis of the current status of Helicobacter pylori infection, antibiotic resistance, and associated factors in patients at a Grade B tertiary hospital

doi: 10.16766/j.cnki.issn.1674-4152.004410

  • Department of Gastroenterology, Chun'an Branch of Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 311700, China

Funds:

 2022KY1073

  • Received Date: 2025-03-06
    Available Online: 2026-06-02
    Abstract
  •   Objective  To investigate the current status of Helicobacter pylori infection and its antibiotic resistance profile in a specific patient population at our hospital, and to analyze the association between the resistance patterns and factors such as sex and age. The findings aim to provide evidence to support individualized H. pylori eradication therapy in this region.  Methods  A total of 214 patients who underwent gastroscopy at the Chun'an Branch of Zhejiang Provincial People's Hospital between January 2022 and February 2023 were enrolled. Gastric mucosal specimens were collected from them for Hp culture and drug susceptibility testing to assess the prevalence of Hp infection and antibiotic resistance patterns.  Results  Among the 214 patients, 81 were tested positive for Hp infection, yielding an Hp infection rate of 37.85%. Among the 81 isolated Hp strains, resistance to six antibiotics were evaluated. The highest resistance rate was observed for metronidazole (76.54%), followed by amoxicillin (41.98%), and clarithromycin (20.99%). The difference in resistance rates among the six antibiotics was statistically significant (P < 0.001). Regarding resistance patterns, 39.51% of strains exhibited single-drug resistance, 32.10% showed dual resistance, 17.28% demonstrated triple resistance, and 3.70% exhibited multiple (over 3 types) resistance. Among patients with metronidazole monoresistance, those aged 50-64 years had the highest resistance rate (90.00%), whereas patients aged 18-29 years had the lowest resistance rate (46.15%).  Conclusion  The prevalence of Helicobacter pylori infection rate among patients in our hospital is lower than that reported in national epidemiological surveys, while the overall antibiotic resistance rate remains relatively high. The resistance rates to metronidazole, amoxicillin, and clarithromycin show an increasing trend, and age-related differences are observed in metronidazole monoresistance. Regional hospitals should perform susceptibility testing and implement targeted H. pylori eradication strategies based on resistance profiles.

     

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