Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 403-406
Alidan · Aierken, LI Mingyuan, Wangminawaer · Hujiaaihemaiti. Correlation between the characteristics of right ventricular remodeling and therapeutic response in patients with pulmonary hypertension[J]. Chinese Journal of General Practice, 2026, 24(3): 403-406. doi: 10.16766/j.cnki.issn.1674-4152.004406
Citation: Alidan · Aierken, LI Mingyuan, Wangminawaer · Hujiaaihemaiti. Correlation between the characteristics of right ventricular remodeling and therapeutic response in patients with pulmonary hypertension[J]. Chinese Journal of General Practice, 2026, 24(3): 403-406. doi: 10.16766/j.cnki.issn.1674-4152.004406
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Correlation between the characteristics of right ventricular remodeling and therapeutic response in patients with pulmonary hypertension

doi: 10.16766/j.cnki.issn.1674-4152.004406

  • Department of General Practice, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China

Funds:

 2022D01C476

  • Received Date: 2025-03-15
    Available Online: 2026-06-02
    Abstract
  •   Objective  Exploring the relationship between right ventricular remodeling characteristics and treatment responsiveness in patients with pulmonary arterial hypertension(PAH), providing insights for a more accurate assessment of patient prognosis.  Methods  A total of 102 PAH patients who visited the First Affiliated Hospital of Xinjiang Medical University from April 2020 to April 2024 were enrolled in this study. According to their treatment responsiveness, they were divided into a responsive group (n=79) and a non-responsive group (n=23). The differences in general clinical data, right-heart catheterization parameters before treatment, echocardiogram parameters, and cardiopulmonary function between the two groups were compared. Spearman analysis and logistic regression analysis were performed to screen out the risk factors for non-responsiveness to treatment in PAH patients.  Results  The proportion of patients with hypertension, mean pulmonary artery systolic pressure (PASP), pulmonary vascular resistance (PVR), transpulmonary gradient (TPG), the ratio of right-ventricular anterior-posterior diameter to left-ventricular anterior-posterior diameter at end-systole (RVADs/LVADs), the ratio of right-ventricular transverse diameter to left-ventricular transverse diameter at end-diastole (RVTDd/LVTDd), the ratio of right-ventricular transverse diameter to left-ventricular transverse diameter at end-systole (RVTDs/LVTDs), right-ventricular end-diastolic volume (3DRVEDV), and the Brog dyspnea score in the non-responsive group were significantly higher than those in the responsive group (P < 0.05). Spearman correlation analysis and logistic regression analysis showed that PVR, TPG, RVADs/LVADs, and 3DRVEDV were all important risk factors for non-responsiveness to treatment in PAH patients (OR=4.716, 2.083, 6.379, 1.721, all P < 0.05).  Conclusion  There is a significant correlation between the severity of right ventricular remodeling and non-responsiveness to treatment in PAH patients. Timely right-heart catheterization and echocardiogram have great clinical significance for evaluating the treatment prognosis of PAH patients.

     

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