Volume 24 Issue 3
Mar.  2026
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Article Navigation >  Chinese Journal of General Practice  > 2026  >  24(3): 399-402
LIN Limiao, YUAN Zihui, WANG Weizhong, SHAO Xiaoxiao, XU Yuan, CAO Shuguang, JIANG Yi. Associations of FCGR3A gene polymorphisms with the risk of ulcerative colitis[J]. Chinese Journal of General Practice, 2026, 24(3): 399-402. doi: 10.16766/j.cnki.issn.1674-4152.004405
Citation: LIN Limiao, YUAN Zihui, WANG Weizhong, SHAO Xiaoxiao, XU Yuan, CAO Shuguang, JIANG Yi. Associations of FCGR3A gene polymorphisms with the risk of ulcerative colitis[J]. Chinese Journal of General Practice, 2026, 24(3): 399-402. doi: 10.16766/j.cnki.issn.1674-4152.004405
shu

Associations of FCGR3A gene polymorphisms with the risk of ulcerative colitis

doi: 10.16766/j.cnki.issn.1674-4152.004405
  • 1.

    Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 LY23H030004

 2024ZL616

 Y20240212

  • Received Date: 2025-04-25
    Available Online: 2026-06-02
    Abstract
  •   Objective  To investigate the association between FCGR3A gene polymorphisms and the risk of ulcerative colitis (UC), disease location, and clinicopathological features related to disease activity.  Methods  From January 2012 to January 2021, 545 UC patients and 545 age- and gender-matched healthy controls were recruited from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The modified Mayo score was employed to assess the disease activity of UC. The FCGR3A polymorphisms (rs396991 and rs4656317) were genotyped using MALDI-TOF mass spectrometry. Haplotype analysis and linkage disequilibrium assessment were performed with Haploview 4.2 software.  Results  Genotype analysis revealed that the frequency of the C allele at rs396991 was significantly higher in UC patients than in healthy controls (P=0.025), and the frequencies of the C allele and its carriers at rs4656317 were also markedly elevated (both P < 0.001). The frequencies of the variant allele and genotype of rs396991 in patients with moderate-to-severe active UC were both higher than those in patients with mild active UC (P=0.012 and P=0.032, respectively). The rs4656317 and rs396991 loci of theFCGR3A gene exhibited strong linkage disequilibrium (D'=0.920, r2=0.667). Haplotype analysis demonstrated that the frequencies of AG (P=0.003) and CG (P=0.006) haplotypes were decreased, while those of CC (P=0.002) and AC (P=0.005) haplotypes were increased in the UC group; furthermore, the AG haplotype was downregulated and the CC haplotype was upregulated in moderate-to-severe active UC patients (P=0.032 and 0.003, respectively).  Conclusion  FCGR3A (rs396991, rs4656317) gene variations may be risk factors for UC. In addition, FCGR3A (rs396991) gene variation may also be related to the increased disease activity in UC patients.

     

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