Volume 29 Issue 10
Oct.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1748-1752
GUAN Yanli, ZHANG Li, PEI Lijuan, ZHANG Mei. Prognostic effect of ultrasonic arterial flow parameters combined with serum ACA and AMH detection on fetal saving outcome of threatened abortion[J]. Chinese Journal of General Practice, 2025, 23(10): 1748-1752. doi: 10.16766/j.cnki.issn.1674-4152.004220
Citation: GUAN Yanli, ZHANG Li, PEI Lijuan, ZHANG Mei. Prognostic effect of ultrasonic arterial flow parameters combined with serum ACA and AMH detection on fetal saving outcome of threatened abortion[J]. Chinese Journal of General Practice, 2025, 23(10): 1748-1752. doi: 10.16766/j.cnki.issn.1674-4152.004220
shu

Prognostic effect of ultrasonic arterial flow parameters combined with serum ACA and AMH detection on fetal saving outcome of threatened abortion

doi: 10.16766/j.cnki.issn.1674-4152.004220
  • 1.

    Ultrasound Department, Sanmenxia Hospital of the Yellow River, Sanmenxia, Henan 472000, China

Funds:

 LHGJ202101113

  • Received Date: 2025-01-05
    Abstract
  •   Objective  Threatened abortion (TA) may still lead to abortive failure after treatment. In this study, ultrasound arterial flow parameters in combination with serum anti-cardiolipin antibody (ACA) and anti-Mullerian hormone (AMH) were detected to explore the predictive effect of these indicators on abortive outcome, with a view to improving the success rate of TA.  Methods  The current study is based on a total of 135 TA patients admitted to Sanmenxia Hospital and Nanyang Central Hospital of the Yellow River from May 2021 to May 2023. According to the outcome of fetal protection, they were divided into a successful group (n=83) and a failed group (n=52). All patients had their ultrasonic arterial blood flow parameters and serum hormone levels checked. The influencing factors of fetal survival outcome were analyzed by means of a logistic regression model. The receiver operating characteristic (ROC) curve was utilized to analyze the predictive value of ultrasonic arterial flow parameters, serum ACA and AMH in the outcome of fetal protection.  Results  In contrast with the abortive group, the end-diastolic flow rate (D) and AMH levels in the abortive group were decreased, while the peak systolic flow rate (S)/D, pulse index (PI), resistance index (RI), ACA level and spontaneous abortion history, and the proportion of vaginal bleeding ≥50 mL were increased in the abortive group (P < 0.05). Logistic regression analysis showed that vaginal bleeding of ≥50 mL, elevated high levels of S/D, PI, RI and ACA were independent risk factors for fetal failure of TA (P < 0.05, OR>1), and high levels of AMH were protective factors (P < 0.05, OR < 1). The results of the ROC analysis demonstrated that the AUC of S/D, PI, RI, ACA and AMH were 0.724, 0.676, 0.752, 0.755, 0.692 and 0.880, respectively, and the combined prediction efficiency of the five factors was found to be superior to that of each individual test.  Conclusion  Abnormal ultrasonic arterial flow parameters in TA patients, among which high levels of S/D, PI, RI and ACA are risk factors for the failure of TA, and high levels of AMH are protective risk factors. The five combined tests have a high level of predictive capacity for the outcome of TA.

     

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