Volume 29 Issue 10
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(10): 1685-1688
LIU Minfen, LAN Likang, LYU Jin, LIANG Yanfei, XU Ruyue, WU Hongwei. Efficacy of low frequency transcranial magnetic stimulation combined with cognitive behavioral therapy in patients with Parkinson's disease complicated with sleep disorders[J]. Chinese Journal of General Practice, 2025, 23(10): 1685-1688. doi: 10.16766/j.cnki.issn.1674-4152.004205
Citation: LIU Minfen, LAN Likang, LYU Jin, LIANG Yanfei, XU Ruyue, WU Hongwei. Efficacy of low frequency transcranial magnetic stimulation combined with cognitive behavioral therapy in patients with Parkinson's disease complicated with sleep disorders[J]. Chinese Journal of General Practice, 2025, 23(10): 1685-1688. doi: 10.16766/j.cnki.issn.1674-4152.004205
shu

Efficacy of low frequency transcranial magnetic stimulation combined with cognitive behavioral therapy in patients with Parkinson's disease complicated with sleep disorders

doi: 10.16766/j.cnki.issn.1674-4152.004205

  • Department of Neurology, Lishui People ' s Hospital, Wenzhou Medical College Affiliated Sixth Hospital, Lishui, Zhejiang 323000, China

Funds:

 2022KY1443

  • Received Date: 2025-03-12
    Abstract
  •   Objective  To explore the clinical effect of low-frequency transcranial magnetic stimulation (LF-TMS) combined with cognitive behavioral therapy (CBT) in the treatment of patients with Parkinson ' s disease (PD) complicated with insomnia disorder, and to provide guidance for improving the sleep quality of PD patients.  Methods  A total of 92 patients with PD complicated with sleep disorders admitted to Lishui People ' s hospital from October 2021 to October 2023 were selected and randomly divided into an observation group and a control group, with 46 cases in each group, by the random number table method. Both groups were treated with LF-TMS, and the observation group received CBT intervention on the basis of LF-TMS treatment. The Pittsburgh sleep quality index (PSQI) scale, Parkinson ' s disease sleep scale (PDSS), and cardiopulmonary coupling (CPC)- assessment system were used to evaluate the sleep status before the intervention and at 4 weeks, and the clinical efficacy of the two groups 3 months after the intervention was compared.  Results  The PSQI scale score indicators of the two groups at 4 weeks after the intervention were significantly lower than the corresponding indicators of the same group before the intervention (P < 0.01), and the PDSS scores were significantly higher than the indicators before the intervention (P < 0.01). The PSQI scale score indicators of the observation group at 4 weeks after the intervention were significantly lower than those of the control group at the same period (P < 0.05). The total clinical effective rate of the observation group was significantly higher than that of the control group [44 cases (95.65%) vs. 36 cases (78.26%), χ2=6.133, P=0.013]. Before the intervention, there was no statistically significant difference in the CPC index between the two groups (P>0.05). After the intervention, the above indicators in the observation group were significantly better than those in the control group (P < 0.01).  Conclusion  The utilization of LF-TMS in conjunction with CBT in the treatment of PD patients with sleep disorders has significant clinical effect, which can significantly improve the sleep disorders of PD patients and improve the sleep quality.

     

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