Volume 23 Issue 5
May  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(5): 853-857
HE Ju, SHEN Dan. Clinical study on self-made Bushen Yanggan Decoction combined with Dingkundan in the treatment of premature ovarian failure[J]. Chinese Journal of General Practice, 2025, 23(5): 853-857. doi: 10.16766/j.cnki.issn.1674-4152.004017
Citation: HE Ju, SHEN Dan. Clinical study on self-made Bushen Yanggan Decoction combined with Dingkundan in the treatment of premature ovarian failure[J]. Chinese Journal of General Practice, 2025, 23(5): 853-857. doi: 10.16766/j.cnki.issn.1674-4152.004017
shu

Clinical study on self-made Bushen Yanggan Decoction combined with Dingkundan in the treatment of premature ovarian failure

doi: 10.16766/j.cnki.issn.1674-4152.004017
  • 1.

    Department of Gynecology, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang 312000, China

Funds:

 2022ZB234

  • Received Date: 2024-07-23
    Available Online: 2025-08-14
    Abstract
  •   Objective  To explore the effect of self-made Bushen Yanggan Decoction combined with Dingkundan on the changes of sex hormones and glucose and lipid metabolism in patients with premature ovarian insufficiency, and analyze its role in improving the quality of life of patients.  Methods  A total of 97 cases of premature ovarian insufficiency treated in Shaoxing Hospital of Traditional Chinese Medicine from June 2022 to March 2024 were selected as the research object, and divided into western medicine (WM) group (48 cases) and traditional Chinese medicine (TCM) group (49 cases) according to the treatment regimen taken. The WM group received hormone therapy from western medicine, while the TCM group was treated with Dingkundan combined with self-made Bushen Yanggan Decoction. The curative effect of TCM syndrome, changes of sex hormones, glucose and lipid metabolism level and quality of life were compared between the two groups after treatment.  Results  The total effective rate of TCM group was higher than that of WM group [91.84% (45/49) vs. 75.00% (36/48), χ2=4.990, P=0.025]. HbA1c [(4.84±0.80)% vs. (5.18±0.73)%, P < 0.05] and other glucose and lipid metabolism levels in TCM group were lower than those in WM group. The luteinizing hormone/follicular stimulating hormone ratio of TCM group (1.93±0.65 vs. 3.00±0.91) was lower than that of WM group (P < 0.001). The quality of life scores in TCM group were significantly higher than those in WM group at 4 weeks [(69.22±7.21) points vs. (64.29±8.02) points], 8 weeks [(80.29±8.63) points vs. (70.63±6.34) points], and 12 weeks [(86.39±4.15) points vs. (72.33±4.38) points] after treatment (P < 0.05).  Conclusion  Self-made Bushen Yanggan Decoction combined with Dingkundan has obvious and sustained benefits in improving sex hormones, glucose and lipid metabolism and quality of life in patients with premature ovarian failure, and it is safe and worthy of clinical promotion.

     

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