Volume 23 Issue 5
May  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(5): 823-826
HE Jianxin, ZHANG Hongbin, LOU Yunyan. Clinical value of NOC2L combined with SLFN11 detection in the evaluation of liver cancer condition and prognosis[J]. Chinese Journal of General Practice, 2025, 23(5): 823-826. doi: 10.16766/j.cnki.issn.1674-4152.004010
Citation: HE Jianxin, ZHANG Hongbin, LOU Yunyan. Clinical value of NOC2L combined with SLFN11 detection in the evaluation of liver cancer condition and prognosis[J]. Chinese Journal of General Practice, 2025, 23(5): 823-826. doi: 10.16766/j.cnki.issn.1674-4152.004010
shu

Clinical value of NOC2L combined with SLFN11 detection in the evaluation of liver cancer condition and prognosis

doi: 10.16766/j.cnki.issn.1674-4152.004010
  • 1.

    Department of Laboratory Medicine, Yiwu Central Hospital, Yiwu, Zhejiang 322000, China

Funds:

 2024KY507

  • Received Date: 2024-10-09
    Available Online: 2025-08-14
    Abstract
  •   Objective  NOC2L and SLFN11 are closely related to the pathogenesis of malignant tumors. The clinical value of NOC2L combined with SLFN11 detection in liver cancer was studied.  Methods  The expression of NOC2L and SLFN11 was detected in 95 patients with liver cancer (HCC group) and 51 patients with benign liver diseases (control group) treated in Yiwu Central Hospital from January 2020 to December 2021, and the relationship with prognosis and survival was analyzed.  Results  NOC2L in tumor tissue of HCC group was higher than that in adjacent tissue and control group (1.26±0.25 vs. 0.72±0.11, 0.69±0.13, F=264.577, P < 0.001), while SLFN11 was lower than that in adjacent tissue and control group (0.78±0.12 vs. 0.96±0.17, 0.98±0.15, F=46.396, P < 0.001). In the HCC group, NOC2L expression was positively correlated with pathological grade, primary tumor T stage, number of metastatic lymph nodes, distant metastasis, and TNM stage (all rs>0, P < 0.05), while SLFN11 expression was negatively correlated (all rs < 0, P < 0.05). The efficacy of SLFN11 combined with NOC2L detection in predicting poor prognosis of liver cancer was higher than that of NOC2L and SLFN11 alone (P < 0.05). NOC2L≥1.26 and SLFN11≤0.78 were independent risk factors for poor prognosis of liver cancer (P < 0.05). The median survival of patients with NOC2L≥1.26 and SLFN11≤0.78 was lower than that of patients with NOC2L < 1.26 or SLFN11>0.78 (log-rank χ2=14.618, P < 0.001).  Conclusion  The expression of NOC2L and SLFN11 in liver cancer can provide objective evidence for the evaluation of liver cancer disease and prognosis. The combination of the two can significantly improve the value of predicting disease and prognosis.

     

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