Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children

HE Lidan; WANG Hong; CAI Zhendang; CHEN Fujiang

doi:10.16766/j.cnki.issn.1674-4152.004005

Volume 23 Issue 5

May 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(5): 802-805

HE Lidan, WANG Hong, CAI Zhendang, CHEN Fujiang. Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children[J]. Chinese Journal of General Practice, 2025, 23(5): 802-805. doi: 10.16766/j.cnki.issn.1674-4152.004005

Citation:

HE Lidan, WANG Hong, CAI Zhendang, CHEN Fujiang. Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children[J]. Chinese Journal of General Practice, 2025, 23(5): 802-805. doi: 10.16766/j.cnki.issn.1674-4152.004005

Citation:

HE Lidan, WANG Hong, CAI Zhendang, CHEN Fujiang. Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children[J]. Chinese Journal of General Practice, 2025, 23(5): 802-805. doi: 10.16766/j.cnki.issn.1674-4152.004005

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Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children

doi: 10.16766/j.cnki.issn.1674-4152.004005

1.
Department of Pediatrics, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

2021KY1059

Received Date: 2024-11-21
Available Online: 2025-08-14

Abstract

Abstract

Objective To improve the therapeutic efficacy of Helicobacter pylori (Hp)-positive peptic ulcer (PU) in children, this study investigates the clinical outcomes and mechanistic effects of combining Bifidobacterium quadruple viable tablets with quadruple therapy, focusing on their impacts on intestinal immune function and cytokine levels. Methods A total of 160 children with Hp positive peptic ulcers admitted to Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from December 2021 to January 2024 were included and randomly divided into a control group (80 cases) and an observation group (80 cases). The control group received quadruple therapy (including two kinds of antibiotics, a proton pump inhibitor, and a bismuth agent), while the observation group received treatment with Bifidobacterium quadruple live bacterial tablets in addition to quadruple therapy. The therapeutic effect level of peptic ulcers was evaluated. The levels of serum pepsinogen (PG), gastrin (GAS), and cytokines were measured before and after treatment. The T-helper 17 (Th17)/regulatory T cells (Treg) immune balance status were analyzed. The Hp conversion to negative and recurrence of peptic ulcers 6 months after treatment were statistical analysis. The adverse drug reactions were observed. Results The overall effective rate of treatment in observation group (93.75%, 75/80) was higher than control group (81.25%, 65/80, P < 0.001). After 2 weeks of treatment, the serum levels of PG Ⅰ, PG Ⅱ, GAS in the observation group were lower than those of control group (P < 0.001), and the contents of serum Th17, Treg, Th17/Treg, IL-17, and TGF in the observation group were lower than control group (P < 0.001). The Hp seroconversion rate in the observation group after treatment (88.75%, 71/80) was significantly higher than that in the control group (73.75%, 59/80), while the recurrence rate of peptic ulcers at 6 months after treatment (8.75%, 7/80) was significantly lower than that in the control group (22.50%, 18/80, P < 0.001). The difference in the incidence of adverse drug reactions between the two treatment groups was not statistically significant (P>0.05). Conclusion The combination of bifidobacterium quadruple active tablets and quadruple therapy can improve intestinal cellular immune function, alleviate and reduce the severity of intestinal inflammatory reactions by inhibiting the secretion of gastric protease and gastrin, thereby enhancing the therapeutic effect of Hp positive PU in children and promoting Hp negative conversion rate. It can also prevent and reduce the risk of PU recurrence with fewer adverse reactions.
- Bifidobacterium quadruplex live bacterial tablets,
- Helicobacter pylori,
- Peptic ulcer,
- Immune function,
- Inflammatory reaction

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References(21)

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Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children

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Study on the mechanism of action of bifidobacterium quadruple active tablets combined with quadruple therapy in the treatment of Hp positive peptic ulcers in children

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