Prediction analysis of risk factors and TSP1, FOXP 3 levels in children with severe Mycoplasma pneumonia

ZHAO Hui; PAN Yule; Gulibaha Maimaiti; LIU Yu

doi:10.16766/j.cnki.issn.1674-4152.004004

Volume 23 Issue 5

May 2025

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Article Navigation > Chinese Journal of General Practice > 2025 > 23(5): 798-801

ZHAO Hui, PAN Yule, Gulibaha Maimaiti, LIU Yu. Prediction analysis of risk factors and TSP1, FOXP 3 levels in children with severe Mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2025, 23(5): 798-801. doi: 10.16766/j.cnki.issn.1674-4152.004004

Citation:

ZHAO Hui, PAN Yule, Gulibaha Maimaiti, LIU Yu. Prediction analysis of risk factors and TSP1, FOXP 3 levels in children with severe Mycoplasma pneumonia[J]. Chinese Journal of General Practice, 2025, 23(5): 798-801. doi: 10.16766/j.cnki.issn.1674-4152.004004

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Prediction analysis of risk factors and TSP1, FOXP 3 levels in children with severe Mycoplasma pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.004004

ZHAO Hui¹
, PAN Yule²
, Gulibaha Maimaiti^{1
,
,}
, LIU Yu¹

1.
Department of Pediatrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, China

Funds:

SKL-HIDCA-2021-JH3

Received Date: 2024-08-28
Available Online: 2025-08-14

Abstract

Abstract

Objective In the onset process of children with severe Mycoplasma pneumonia, a certain proportion of children will have plastic bronchitis (PB). The aim is to explore the pathogenesis and analyzed the predictive value of thrombine-sensitive protein 1 (TSP1) and forked head spiral transcription factor 3 (FOXP3) levels for plastic bronchitis. Methods A total of 320 children with severe Mycoplasma pneumonia admitted to the First Affiliated Hospital of Xinjiang Medical University from June 2020 to June 2024 were selected and divided into PB group (120 cases) and non-PB group (200 cases). Univariate and multivariate factors were used to analyze the risk factors of PB in children with severe Mycoplasma pneumonia. TSP1 and FOXP3 levels were measured by ELISA. ROC evaluated the predictive value of TSP1 and FOXP3 for plastic bronchitis. Results Multivariate logistic regression analysis showed that fever duration ≥8 d, tachypnea, pleural effusion, white blood cell count ≥8.10×10⁹/L, neutrophil ratio ≥68.10%, lymphocyte ratio < 30%, CRP ≥40 mg/L, LDH ≥450 U/L were the risk factors for PB in children with severe Mycoplasma pneumonia (P < 0.05). Compared with the non-PB group, the expressions of TSP1 [(54.68±9.00) ng/mL] and FOXP3 (3.08±0.51) were increased in PB group [(66.71±12.17) ng/mL and 3.92±0.69, P < 0.05]. ROC results showed that compared with the single diagnosis of TSP1 and FOXP3, the combination of the two had higher diagnostic value (P < 0.05). Conclusion The duration of fever, tachypnea, pleural effusion, white blood cell count, neutrophil ratio, lymphocyte ratio, CRP and LDH are risk factors for plastic bronchitis in children with severe Mycoplasma pneumonia. TSP1 and FOXP3 have high value in predicting plastic bronchitis.
- Severe Mycoplasma pneumonia,
- Plastic bronchitis,
- Thrombin-sensitive protein 1,
- Forked head spiral transcription factor 3

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References(20)

References

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