Volume 21 Issue 12
Dec.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2086-2088
BAI Min, HUANG Lieping, ZHU Bei, WU Jinhua, WU Qiong, HONG Kaiting, YU Youna. Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children[J]. Chinese Journal of General Practice, 2023, 21(12): 2086-2088. doi: 10.16766/j.cnki.issn.1674-4152.003296
Citation: BAI Min, HUANG Lieping, ZHU Bei, WU Jinhua, WU Qiong, HONG Kaiting, YU Youna. Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children[J]. Chinese Journal of General Practice, 2023, 21(12): 2086-2088. doi: 10.16766/j.cnki.issn.1674-4152.003296
shu

Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children

doi: 10.16766/j.cnki.issn.1674-4152.003296
  • 1.

    Department of Pediatrics, Zhoushan Women's and Children's Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 2023KY1305

  • Received Date: 2023-05-24
    Available Online: 2024-01-29
    Abstract
  •   Objective  Paediatric non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and its prevalence is increasing with the rise in overweight and obesity. Leptin was the first adipokine to be isolated and identified. Therefore, the mediating role of leptin levels between insulin resistance and NAFLD in obese children is discussed.  Methods  Eighty obese children admitted to Zhoushan Women's and Children's Hospital from January 2022 to March 2023 were selected as research objects, and divided into NAFLD group (32 cases) and non-NAFLD group (48 cases) according to the presence or absence of NAFLD. General data, physical data, insulin resistance index, leptin level and liver function of all subjects were collected, and Pearson correlation was used to analyze the correlation between the above variables. Mediation effects were used to analyze the effects of leptin levels on insulin resistance and non-alcoholic fatty liver disease in obese children.  Results  Homeostasis model assessment forinsulin resistance (HOMA-IR), leptin, alanine transaminase (ALT), aspartate transaminase (AST) and intrahepatic lipiol (IHL) levels in the NAFLD group were higher than those in the non-NAFLD group (all P < 0.05). Pearson correlation showed that HOMA-IR was positively correlated with leptin and IHL (r=0.573, P < 0.001; r=0.577, P < 0.001); leptin was positively correlated with IHL (r=0.557, P < 0.001). Mediation effect analysis showed that HOMA-IR as a direct effect accounted for 56.48% (0.340) of the total effect and adipokines as a mediating effect accounted for 43.52% (0.262).  Conclusion  Insulin resistance in obese children is associated with non-alcoholic fatty liver disease, which may be mediated by adipokines.

     

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    • References(23)
  • [1]
    POWELL E E, WONG V W, RINELLA M. Non-alcoholic fatty liver disease[J]. Lancet, 2021, 397(10290): 2212-2224. doi: 10.1016/S0140-6736(20)32511-3
    [2]
    BRUNNER K T, HENNEBERG C J, WILECHANSKY R M, et al. Nonalcoholic fatty liver disease and obesity treatment[J]. Curr Obes Rep, 2019, 8(3): 220-228. doi: 10.1007/s13679-019-00345-1
    [3]
    FRIEDMAN S L, NEUSCHWANDER-TETRI B A, RINELLA M, et al. Mechanisms of NAFLD development and therapeutic strategies[J]. Nat Med, 2018, 24(7): 908-922. doi: 10.1038/s41591-018-0104-9
    [4]
    PEREIRA S, CLINE D L, GLAVAS M M, et al. Tissue-specific effects of leptin on glucose and lipid metabolism[J]. Endocr Rev, 2021, 42(1): 1-28. doi: 10.1210/endrev/bnaa027
    [5]
    SETH M, BISWAS R, GANGULY S, et al. Leptin and obesity[J]. Physiol Int, 2020, 107(4): 455-468.
    [6]
    GUZZARDI M A, GUIDUCCI L, CAMPANI D, et al. Leptin resistance before and after obesity: evidence that tissue glucose uptake underlies adipocyte enlargement and liver steatosis/steatohepatitis in Zucker rats from early-life stages[J]. Int J Obes (Lond), 2022, 46(1): 50-58. doi: 10.1038/s41366-021-00941-z
    [7]
    PETRESCU M, VLAICU S I, CIUMǍRNEAN L, et al. Chronic inflammation-a link between nonalcoholic fatty liver disease (NAFLD) and dysfunctional adipose tissue[J]. Medicina (Kaunas), 2022, 58(5): 641. doi: 10.3390/medicina58050641
    [8]
    中国肥胖问题工作组. 中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J]. 中华流行病学杂志, 2004, 25(2): 97-102. doi: 10.3760/j.issn:0254-6450.2004.02.003

    China Working Group on Obesity. Body mass index reference norm for screening overweight and obesity in Chinese children and adolescents[J]. Chinese Journal of Epidemiology, 2004, 25(2): 97-102. doi: 10.3760/j.issn:0254-6450.2004.02.003
    [9]
    中华医学会儿科分会内分泌遗传代谢学组. 儿童非酒精性脂肪肝病诊断与治疗专家共识[J]. 中国实用儿科杂志, 2018, 33(7): 487-491.

    Endocrinology, Genetics and Metabolism Group, Pefiatric Society, Chinese Medical Association. Expert consensus on the diagnosis and treatment of nonalcoholic fatty liver disease in children[J]. Chinese Journal of Practical Pediatrics, 2018, 33(7): 487-491.
    [10]
    CHAO H W, CHAO S W, LIN H, et al. Homeostasis of glucose and lipid in non-alcoholic fatty liver disease[J]. Int J Mol Sci, 2019, 20(2): 298. doi: 10.3390/ijms20020298
    [11]
    王声翰, 杨菊红, 郑妙艳, 等. 可溶性CD36与2型糖尿病及其并发症的关系[J]. 中华全科医学, 2020, 18(11): 1921-1924. doi: 10.16766/j.cnki.issn.1674-4152.001654

    WANG S H, YANG J H, ZHENG M Y, et al. Association of soluble CD36 with type 2 diabetes and its complications[J]. Chinese Journal of General Practice, 2020, 18(11): 1921-1924. doi: 10.16766/j.cnki.issn.1674-4152.001654
    [12]
    LEWIS G F, CARPENTIER A C, PEREIRA S, et al. Direct and indirect control of hepatic glucose production by insulin[J]. Cell Metab, 2021, 33(4): 709-720. doi: 10.1016/j.cmet.2021.03.007
    [13]
    SHEKA A C, ADEYI O, THOMPSON J, et al. Nonalcoholic steatohepatitis: a review[J]. JAMA, 2020, 323(12): 1175-1183. doi: 10.1001/jama.2020.2298
    [14]
    SCHWIMMER J B, JOHNSON J S, ANGELES J E, et al. Microbiome signatures associated with steatohepatitis and moderate to severe fibrosis in children with nonalcoholic fatty liver disease[J]. Gastroenterology, 2019, 157(4): 1109-1122. doi: 10.1053/j.gastro.2019.06.028
    [15]
    BERNDT N, HUDERT C A, ECKSTEIN J, et al. Alterations of central liver metabolism of pediatric patients with non-alcoholic fatty liver disease[J]. Int J Mol Sci, 2022, 23(19): 11072. doi: 10.3390/ijms231911072
    [16]
    李婧, 李小凤, 闫妮, 等. 评估肥胖相关指标对非酒精性脂肪肝的筛查价值[J]. 中华全科医学, 2023, 21(2): 195-198. doi: 10.16766/j.cnki.issn.1674-4152.002843

    LI J, LI X F, YAN N, et al. Evaluation the screening value of obesity-related indices for non-alcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2023, 21(2): 195-198. doi: 10.16766/j.cnki.issn.1674-4152.002843
    [17]
    VATIER C, JÉRU I, FELLAHI S, et al. Leptin, adiponectin, lipodystrophic and severe insulin resistance syndromes[J]. Ann Biol Clin (Paris), 2020, 78(3): 261-264.
    [18]
    BRAND C, GAYA A, DIAS A F, et al. Relationship between insulin resistance and adipocytokines: the mediator role of adiposity in children[J]. Ann Hum Biol, 2020, 47(3): 244-249. doi: 10.1080/03014460.2020.1740320
    [19]
    KADO T, NAWAZ A, TAKIKAWA A, et al. Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis[J]. Sci Rep, 2019, 9(1): 12284. doi: 10.1038/s41598-019-48678-0
    [20]
    MICU E S, AMZOLINI A M, BARǍU ABU-ALHIJA A, et al. Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects[J]. Rom J Morphol Embryol, 2021, 62(2): 509-515.
    [21]
    DUDEK M, PFISTER D, DONAKONDA S, et al. Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH[J]. Nature, 2021, 592(7854): 444-449. doi: 10.1038/s41586-021-03233-8
    [22]
    LEE J K, HA J H, KIM D K, et al. Depletion of zinc causes osteoblast apoptosis with elevation of leptin secretion and phosphorylation of JAK2/STAT3[J]. Nutrients, 2022, 15(1): 77. doi: 10.3390/nu15010077
    [23]
    OSINSKI V, BAUKNIGHT D K, DASA S, et al. In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects[J]. Theranostics, 2020, 10(2): 585-601. doi: 10.7150/thno.36572
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