Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1147-1149
DING Rong, HUANG Qiaoling, CHEN Zhiwei, PAN Qianxiong. Efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function[J]. Chinese Journal of General Practice, 2023, 21(7): 1147-1149. doi: 10.16766/j.cnki.issn.1674-4152.003070
Citation: DING Rong, HUANG Qiaoling, CHEN Zhiwei, PAN Qianxiong. Efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function[J]. Chinese Journal of General Practice, 2023, 21(7): 1147-1149. doi: 10.16766/j.cnki.issn.1674-4152.003070
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Efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function

doi: 10.16766/j.cnki.issn.1674-4152.003070
  • 1.

    Skin Department, Ruian Hospital of Traditional Chinese Medicine, Wenzhou, Zhejiang 325200, China

Funds:

 2019KY503

  • Received Date: 2023-02-20
    Available Online: 2023-08-28
    Abstract
  •   Objective  To observe the efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function, and provide theoretical reference for clinical treatment of psoriasis.  Methods  A total of 60 patients with psoriasis treated in Ruian Hospital of Traditional Chinese Medicine from February 2019 to November 2022 were selected and randomly divided into two groups by random table method, with 30 cases in each group. The control group were treated with calcipotriol ointment combined with NB-UVB, and the observation group were treated with self-designed Shufeng Jiedu formula on the basis of the control group. Both groups had a treatment course of 8 weeks. The clinical efficacy was evaluated by the psoriasis skin lesion area and severity index (PASI), and the changes in traditional Chinese medicine syndrome scores, immune function (CD3+, CD4+, CD8+, CD4+/CD8+) levels, and safety between two groups of patients before and after treatment were compared.  Results  After treatment, the total effective rate of the observation group was 96.67% (29/30), which was significantly higher than 73.33% (22/30) of the control group (χ2=4.706, P=0.030); the score of severe itching, punctate bleeding and rash increase in the observation group were lower than those in the control group (all P<0.01); the PASI score index of the observation group were lower than that of the control group (all P<0.01); the levels of peripheral blood CD3+, CD4+ and CD4+/CD8+in the observation group were higher than those in the control group [(52.86±6.13)% vs. (45.48±5.57)%, (53.42±5.76)% vs. (48.19±5.24)%, 1.90±0.35 vs. 1.62±0.39, t=4.880, 3.679, 2.927, all P<0.01], however, CD8+ was lower than the control group [(28.25±5.35)% vs. (31.43±5.07)%, t=2.363, P=0.011].  Conclusion  Self-designed Shufeng Jiedu formula combined with calcipotriol exert certain effect in treating of psoriasis, which can significantly improve the PASI score index and the main syndrome score. Its mechanism may be related to the regulation of immune function, and the safety is good.

     

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