Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1641-1644
YU Ting, ZHU Feng, LIN lin, TANG Yu-rong. Impact of combined upper gastrointestinal symptoms on anxiety, depression and quality of life of patients with functional constipation[J]. Chinese Journal of General Practice, 2022, 20(10): 1641-1644. doi: 10.16766/j.cnki.issn.1674-4152.002668
Citation: YU Ting, ZHU Feng, LIN lin, TANG Yu-rong. Impact of combined upper gastrointestinal symptoms on anxiety, depression and quality of life of patients with functional constipation[J]. Chinese Journal of General Practice, 2022, 20(10): 1641-1644. doi: 10.16766/j.cnki.issn.1674-4152.002668
shu

Impact of combined upper gastrointestinal symptoms on anxiety, depression and quality of life of patients with functional constipation

doi: 10.16766/j.cnki.issn.1674-4152.002668

  • Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds:

 81870378

 82000508

  • Received Date: 2021-12-05
    Available Online: 2022-11-30
    Abstract
  •   Objective   To explore the effect of combined upper gastrointestinal (GI) symptoms on anxiety, depression and health-related quality of life (HRQoL) in patients with functional constipation (FC).   Methods   According to the Rome Ⅳ diagnostic criteria, patients with FC who were admitted to the Gastrointestinal Motility Center of the First Affiliated Hospital of Nanjing Medical University from October 2016 to October 2019 were included. Gastrointestinal symptom rating scale, ZUNG anxiety and depression self-rating scale (SAS and SDS) and concise health questionnaire (SF-36) were used in assessing upper GI symptoms, anxiety and depression and HRQoL.   Results   Among 156 patients with FC, 95 (60.90%) had upper gastrointestinal symptoms: 11(7.05%) only had acid reflux and heartburn, 23(14.74%) only had upper abdominal distension, 11(7.05%) only had belching, 7(4.49%) had acid reflux, heartburn and upper abdominal distension, 32(20.51%) had belching and upper abdominal distension and 11(7.05%) had belching, acid reflux and heartburn. Compared with FC patients without upper GI symptoms, those who had upper GI symptoms show higher scores of SAS and SDS (all P < 0.05), and lower score of role physical, physical functioning, general health, role emotional and mental health (all P < 0.05). Among patients with upper GI symptoms, patients who had both belching and upper abdominal distension show higher scores of SAS and SDS, and lower scores of physical functioning, social functioning and role emotional. Furthermore, combined with both belching and upper abdominal distension and high score of SAS was predictor of poorer SF-36 total score (all P < 0.05).   Conclusion   Acid reflux and heartburn, upper abdominal distension and belching are the most common upper GI symptoms in patients with FC. The combined upper GI symptoms increases anxiety and depression and reduce the HRQoL in the patients.

     

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