Volume 20 Issue 8
Aug.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(8): 1295-1298
SU Bo, YAN Zhen-yu, WANG Xin-xin, QIAN Guo-wu, ZHANG Sen, WANG Jing-xuan. Expression of interleukin-23 in carcinoma tissues and its relationship with clinical prognosis in patients with colorectal cancer[J]. Chinese Journal of General Practice, 2022, 20(8): 1295-1298. doi: 10.16766/j.cnki.issn.1674-4152.002580
Citation: SU Bo, YAN Zhen-yu, WANG Xin-xin, QIAN Guo-wu, ZHANG Sen, WANG Jing-xuan. Expression of interleukin-23 in carcinoma tissues and its relationship with clinical prognosis in patients with colorectal cancer[J]. Chinese Journal of General Practice, 2022, 20(8): 1295-1298. doi: 10.16766/j.cnki.issn.1674-4152.002580
shu

Expression of interleukin-23 in carcinoma tissues and its relationship with clinical prognosis in patients with colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002580
  • 1.

    Department of Pathology, Nanyang Central Hospital, Nanyang, Henan 473000, China

Funds:

 182102311210

  • Received Date: 2021-03-15
    Available Online: 2022-09-26
    Abstract
  •   Objective  To investigate the association between interleukin-23 (IL-23) and colorectal cancer.  Methods  A total of 164 patients with colorectal cancer from January 1, 2015, to December 31, 2016, in Nanyang Central Hospital were enrolled. The expression of IL-23 in the carcinoma tissues of patients with colorectal cancer was detected by immunohistochemical methods. In accordance with the staining intensity score and positive cell count score, the 0-1, 2-3, 4-5 and ≥6 scores were defined as negative, weak positive, moderate positive and strong positive, respectively. The high and low expression of IL-23 in the carcinoma tissues of colorectal cancer in paraffin-embedded section were regarded as "moderate to strong positive" and "negative to positive", respectively. Another 70 patients with colorectal cancer and 35 normal individuals between January 1, 2019, and December 31, 2019, were enrolled as independent verification samples and the difference in the IL-23 expression in the serum of the two groups was compared. The influencing factors of postoperative recurrence in patients with colorectal cancer were analysed by Cox regression model and the clinical efficacy of serum IL-23 expression levels in the diagnosis of colorectal cancer was analysed by receiver operating characteristic (ROC) curve.  Results  In all colorectal cancer patients, there were 119 cases with high expression of IL-23 and the remaing with low expression of IL-23. The IL-23 were mostly expressed in the cytoplasm of cells. The lymph node metastasis (N1-N2), TNM stage (stage Ⅲ) and IL-23 expression (high expression) were independent risk factors affecting the prognosis of patients with CRC (P < 0.01).Compared with the control group, the serum expression level of IL-23 in the colorectal cancer experimental group was significantly increased (t=12.173, P < 0.001). ROC curve results showed that the AUC of IL-23 in the diagnosis of colorectal cancer was 0.935 (95% CI: 0.888-0.981). When the cut-off value was 36.195 ng/mL, the diagnostic sensitivity and specificity were 94.30% and 80.00%, respectively.  Conclusion  High expression of IL-23 is significantly associated with poor prognosis in patients with colorectal cancer. IL-23 could be used as a serological marker of CRC.

     

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