Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database

CHEN Zi-hong; ZHONG Qiang; GAO Jian-quan; WEI Cui

doi:10.16766/j.cnki.issn.1674-4152.002384

Volume 20 Issue 3

Mar. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(3): 487-492

CHEN Zi-hong, ZHONG Qiang, GAO Jian-quan, WEI Cui. Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database[J]. Chinese Journal of General Practice, 2022, 20(3): 487-492. doi: 10.16766/j.cnki.issn.1674-4152.002384

Citation:

CHEN Zi-hong, ZHONG Qiang, GAO Jian-quan, WEI Cui. Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database[J]. Chinese Journal of General Practice, 2022, 20(3): 487-492. doi: 10.16766/j.cnki.issn.1674-4152.002384

Citation:

CHEN Zi-hong, ZHONG Qiang, GAO Jian-quan, WEI Cui. Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database[J]. Chinese Journal of General Practice, 2022, 20(3): 487-492. doi: 10.16766/j.cnki.issn.1674-4152.002384

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Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database

doi: 10.16766/j.cnki.issn.1674-4152.002384

1.
The third area of Oncology Department, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China

Funds:

Z20190380

201902169

Received Date: 2021-04-03
Available Online: 2022-08-13

Abstract

Abstract

Objective To establish a nomogram to predict the overall survival (OS) rate of elderly patients with nasopharyngeal carcinoma (≥ 60 years) by utilising the database of the Surveillance, Epidemiology and End Results (SEER) program. Methods The data of 1 366 elderly patients with nasopharyngeal carcinoma who were diagnosed between 2004 and 2015 from the SEER database were obtained. These patients were randomly divided into training (n=954) and validation (n=412) cohorts. The Cox Proportional hazards regression model was performed to evaluate the prognostic effects of multiple clinicopathologic factors on OS. Significant prognostic factors were combined to build a nomogram. The predictive performance of the nomogram was evaluated via internal (training cohort data) and external validation (validation cohort data) by calculating the index of concordance (C-index) and plotting calibration curves. Results In the training cohort, the results of Cox proportional hazards regression model showed that age at diagnosis, married status, race, grade, histologic type, TNM stage, radiation and chemotherapy were significantly associated with the survival prognosis (P < 0.05). These factors were used to establish the nomogram. The nomogram showed good accuracy in predicting OS rate, with a C-index of 0.732 (95% CI: 0.708-0.756) in internal validation and a C-index of 0.762(95% CI was 0.729-0.795) in external validation. All calibration curves showed excellent consistency between prediction by nomogram and actual observation. Conclusion A novel nomogram for elderly patients with nasopharyngeal carcinoma is established to predict OS in our study and shows good prognostic significance. It can provide medical personnel with accurate and practical predictive tools which can quickly and accurately assess the survival prognosis of patients individually and guide medical personnel in the follow-up treatment of patients.
- Elderly,
- Nasopharyngeal carcinoma,
- Database of the Surveillance, Epidemiology, and End Results program,
- Survival analysis,
- Nomogram

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References(32)

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Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database

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Construction of survival and prognosis nomogram for elderly nasopharyngeal carcinoma (≥ 60 years) based on SEER Database

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