Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2072-2076
QIN Li, GE Li-bin, LIANG Zhen-zhen, CHEN Liang, CHEN Chuan. Correlation between frailty and related serum factors in elderly community[J]. Chinese Journal of General Practice, 2021, 19(12): 2072-2076. doi: 10.16766/j.cnki.issn.1674-4152.002240
Citation: QIN Li, GE Li-bin, LIANG Zhen-zhen, CHEN Liang, CHEN Chuan. Correlation between frailty and related serum factors in elderly community[J]. Chinese Journal of General Practice, 2021, 19(12): 2072-2076. doi: 10.16766/j.cnki.issn.1674-4152.002240
shu

Correlation between frailty and related serum factors in elderly community

doi: 10.16766/j.cnki.issn.1674-4152.002240
  • 1.

    Anting Town Huangdu Community Health Service Center, Jiading District, Shanghai 201804, China

Funds:

 JDKW-2017-W40

 ZY(2018-2020)-CCCX-4004

 沪卫人事[2020]87号

 2019JDJYXX007

  • Received Date: 2020-08-25
    Available Online: 2022-03-02
    Abstract
  •   Objective  To understand the situation of senile frailty in community, analyze the correlation between serum factors and senile frailty, and give corresponding suggestions to community medical staff.  Methods  A total of 375 elderly people who underwent physical examination in Huangdu Community Health Service Center, Anting Town, Jiading District, Shanghai from April to September 2018 were selected as the research subjects. The researchers made their own general data questionnaire.The indexes of blood routine and liver and kidney function were derived from the physical examination database of the elderly in this community. Interleukin-6 (IL-6), insulin growth factor 1 (IGF-1) and other indicators were measured by Shanghai Institute of Traditional Chinese Medicine. Ordered multifactor logistic regression was used to analyze the correlation between senile frailty and the levels of the above serum factors.  Results  (1) Among the 375 elderly patients, 173 were at non-frailty stage, 188 at pre-frailty stage and 14 at frailty stage. The gender, age, educational level, smoking history and drinking history of the elderly with different degrees of frailty had statistical significance (all P < 0.05). (2) Among the serum biochemical indexes of the elderly in the community with different degrees of frailty, only hemoglobin had the differences were statistically significant (P < 0.05). (3) The differences of insulin growth factor (IGF-1), follicle-stimulating hormone (FSH) and estradiol (E2) in special serum biochemical indexes of the elderly in the community with different frailty levels were statistically significant (all P < 0.05). (4)The results of logistic regression analysis showed that the levels of hemoglobin (HB), insulin growth factor (IGF-1), follicle-stimulating hormone (FSH), estradiol (E2) and other factors had no correlation with the occurrence of frailty.  Conclusion  The correlation between serum factors and community geriatric frailty is affected by many factors, so community general practitioners should conduct comprehensive assessment of community geriatric frailty in the early stage.

     

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