Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1721-1724
CHEN Jia-jia, MENG Li-wei, LI Xing-yun. Relationship between ultrasound features and expression of ER, PR, CerbB-2 and Ki-67 in breast cancer[J]. Chinese Journal of General Practice, 2021, 19(10): 1721-1724. doi: 10.16766/j.cnki.issn.1674-4152.002151
Citation: CHEN Jia-jia, MENG Li-wei, LI Xing-yun. Relationship between ultrasound features and expression of ER, PR, CerbB-2 and Ki-67 in breast cancer[J]. Chinese Journal of General Practice, 2021, 19(10): 1721-1724. doi: 10.16766/j.cnki.issn.1674-4152.002151
shu

Relationship between ultrasound features and expression of ER, PR, CerbB-2 and Ki-67 in breast cancer

doi: 10.16766/j.cnki.issn.1674-4152.002151
  • 1.

    Department of Ultrasound, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, China

Funds:

 2021KY369

  • Received Date: 2021-03-12
    Available Online: 2022-02-15
    Abstract
  •   Objective  To analyse the ultrasonographic features of breast cancer patients and their relationship with estrogen receptor (ER), progesterone receptor (PR), CerbB-2 and Ki-67 positive expression so as to provide reference for clinical treatment plan.  Methods  Eighty cases of breast cancer patients in our hospital from January to December 2020 were selected as the research objects. All patients underwent breast ultrasound examination. ER, PR, CerbB-2 and Ki-67 were detected. Pearson correlation analysis was used to explore the relationship between ultrasound imaging characteristics and ER, PR, CerbB-2 and Ki-67 positive expression.  Results  A total of 29 cases had a tumor diameter ≤ 2 cm, 23 cases had regular shape, 35 cases had smooth edges, 36 cases had clear boundaries, 65 cases had hypoechoic or mixed echo, 50 cases had posterior attenuation, 51 cases had rich blood supply, and 24 cases had an aspect ratio ≤ 1. A total of 41 cases had microcalcification, and 41 cases had lymph node metastasis. The positive rates of ER, PR, CerbB-2 and Ki-67 in breast cancer patients were 60.00%, 56.25%, 48.75% and 77.50%, respectively. The edge, border, posterior attenuation and lymph node metastasis were positively correlated with ER (r=0.251, 0.303, 0.213, 0.308, all P < 0.05). The edge of lesion and lymph node metastasis were positively correlated with PR (r=0.065, 0.387, all P < 0.05). Blood supply and lymph node metastasis were positively correlated with CerbB-2 (r=0.184, 0.376, all P < 0.05). Microcalcification was negatively correlated with CerbB-2 (r=-0.023, P < 0.05). The diameter of lesion was positively correlated with Ki-67 (r=0.258, P < 0.05).  Conclusion  A certain correlation exists between the ultrasound characteristics of breast cancer and the positive expression of ER, PR, CerbB-2 and Ki-67.

     

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