Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1218-1223
JIAO Rui, PANG Li-jian, LYU Xiao-dong. Mechanism of San'ao Decoction in treatment of cough variant asthma on the basis of network pharmacology[J]. Chinese Journal of General Practice, 2021, 19(7): 1218-1223. doi: 10.16766/j.cnki.issn.1674-4152.002025
Citation: JIAO Rui, PANG Li-jian, LYU Xiao-dong. Mechanism of San'ao Decoction in treatment of cough variant asthma on the basis of network pharmacology[J]. Chinese Journal of General Practice, 2021, 19(7): 1218-1223. doi: 10.16766/j.cnki.issn.1674-4152.002025
shu

Mechanism of San'ao Decoction in treatment of cough variant asthma on the basis of network pharmacology

doi: 10.16766/j.cnki.issn.1674-4152.002025
  • 1.

    Department of Respiratory, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 100032, China

Funds:

 XLYC1808011

  • Received Date: 2020-04-29
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the mechanism of San'ao Decoction in the treatment of cough variant asthma (CVA).  Methods  The TCMSP database was used to screen the effective components and predict the target of San'ao Decoction. GeneCards and OMIM database were searched to screen the CVA disease target. CytoNCA was used to screen the core target of San'ao Decoction in the treatment of CVA. Cytoscape 3.7.1 was used to establish a compound disease target regulatory network. On the basis of DAVID database, GO and KEGG pathway enrichment analyses were conducted to determine the core targets of San'ao Decoction.  Results  On the basis of TCMSP, 114 effective components and 254 potential targets of San'ao Decoction were obtained. A total of 2 257 targets related to the occurrence and development of CVA were screened. Twenty-eight core targets of San'ao Decoction for CVA treatment were screened by using the network topology analysis plug-in CytoNCA. Total 328 entries were obtained by GO function enrichment analysis, including 264 entries of biological process and 46 entries of molecular function and 18 orders of cell composition, mainly including apoptosis, lipopolysaccharide reaction, mitogen activated protein kinase (MAPK) activity, nitric oxide synthetase activity and other functional pathways. A total of 115 entries were obtained from KEGG pathway enrichment analysis, mainly including MAPK signalling pathway, tumour necrosis factor signalling pathway, Th17 cell differentiation and other pathways.  Conclusion  On the basis of network pharmacology, the overall regulatory characteristics of San'ao Decoction in the treatment of CVA, including multi-component, multi-target and multi-channel, are preliminarily discussed and verified, and the potential mechanism of San'ao Decoction in the treatment of CVA is predicted so as to provide scientific basis for the research of its active components.

     

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