Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1147-1149
WANG Nan, QUAN Li-mei, ZHANG Gen-qin, DAI Xi-wang, CHEN Qian, JIN Yan, WU Lin-lin. Analysis of serum 25 hydroxyvitamin D3 and blood lipid levels in patients with gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2021, 19(7): 1147-1149. doi: 10.16766/j.cnki.issn.1674-4152.002007
Citation: WANG Nan, QUAN Li-mei, ZHANG Gen-qin, DAI Xi-wang, CHEN Qian, JIN Yan, WU Lin-lin. Analysis of serum 25 hydroxyvitamin D3 and blood lipid levels in patients with gestational diabetes mellitus[J]. Chinese Journal of General Practice, 2021, 19(7): 1147-1149. doi: 10.16766/j.cnki.issn.1674-4152.002007
shu

Analysis of serum 25 hydroxyvitamin D3 and blood lipid levels in patients with gestational diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.002007
  • 1.

    Department of Obstetrics, Jinhua people's Hospital, Jinhua, Zhejiang 321000, China

Funds:

 2021KY1184

  • Received Date: 2021-03-23
    Available Online: 2022-02-16
    Abstract
  •   Objective  To view the 25-hydroxyvitamin D3[25(OH)D3] in patients with gestational diabetes mellitus (GDM), and view the influences of this level change on the pregnant woman blood sugar and lipid metabolism.  Methods  Total 306 pregnant women admitted to the Department of Obstetrics, Jinhua people's Hospital of Zhejiang Province from May 2018 to December 2019 were selected as the research objects, and their serum 25 (OH) D3 levels, blood glucose and lipid related indicators were detected. According to the results of OGTT test, pregnant women were divided into gestational diabetes mellitus group (n=74) and normal pregnancy group (n=232). The pregnancy outcomes of different subgroups of gestational diabetes mellitus were compared.  Results  The serum 25 (OH) D3 level in GDM group was (55.20±0.06) nmol/L, lower than that in the normal pregnancy group[(64.92±1.10) nmol/L, P < 0.05]. The levels of blood glucose and blood lipid in GDM group were higher than those in the normal pregnancy group. The serum 25 (OH) D3 level was negatively correlated with FPG, TC and TG (all P < 0.05). The gestational age of GDM patients with normal serum 25 (OH) D3 level was (39.20±0.16) weeks, which was higher than that in patients with 25 (OH) D3 deficiency[(36.67±0.51) weeks], and the neonatal weight was greater than that of the patients with 25 (OH) D3 deficiency[(3.72±0.15) kg vs. (3.07±0.12) kg, P < 0.05].  Conclusion  The level of 25 (OH) D3 in patients with gestational diabetes mellitus was lower than that in normal pregnant women, and it was significantly associated with FPG, TC, TG and other glucose and lipid metabolism parameters. If it was lack in the body, it would affect the pregnancy outcome.

     

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