Volume 19 Issue 7
Jul.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(7): 1079-1083
XIE Jing, WANG Dan, YUAN Xu, CHEN Shang-jie, JIANG Yong, WANG Min. Effect of intermittent θ pulse stimulation on frequency spectrum and frequency ratio of EEG in patients with type 2 diabetes mellitus and mild cognitive impairment[J]. Chinese Journal of General Practice, 2021, 19(7): 1079-1083. doi: 10.16766/j.cnki.issn.1674-4152.001989
Citation: XIE Jing, WANG Dan, YUAN Xu, CHEN Shang-jie, JIANG Yong, WANG Min. Effect of intermittent θ pulse stimulation on frequency spectrum and frequency ratio of EEG in patients with type 2 diabetes mellitus and mild cognitive impairment[J]. Chinese Journal of General Practice, 2021, 19(7): 1079-1083. doi: 10.16766/j.cnki.issn.1674-4152.001989
shu

Effect of intermittent θ pulse stimulation on frequency spectrum and frequency ratio of EEG in patients with type 2 diabetes mellitus and mild cognitive impairment

doi: 10.16766/j.cnki.issn.1674-4152.001989
  • 1.

    Department of Rehabilitation Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 81973922

 JCYJ20160427191726109

  • Received Date: 2021-01-25
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the effect of single intermittent θ pulse stimulation on the frequency spectrum and frequency ratio of resting EEG in patients with type 2 diabetes mellitus and mild cognitive impairment.  Methods  From July to November 2020, 40 patients with type 2 diabetes mellitus complicated with mild cognitive impairment were recruited in the community health service center affiliated to Shenzhen Bao 'an Hospital. They were randomly divided into true stimulation group (n=20) and sham stimulation group (n=20). Each patient received a 5 min resting EEG collection first, with a single pulse measurement resting movement threshold, an intermittent θ pulse was stimulated at 80% intensity, and EEG was collected at rest for 5min immediately after stimulation.  Results  After the intervention of intermittent θ pulse stimulation, there was no significant difference in the absolute power of each electrode channel and each frequency band before and after the intervention of sham stimulation group. There was no significant difference in the absolute power of each frequency band of the electrode channel between the sham stimulus group and the true stimulus group. However, in the true stimulation group, the absolute β-band power of T7 and CP6 channels increased significantly after intervention compared with before stimulation, respectively (45.83±8.28) μV2, (39.84±11.10) μV2, the difference was statistically significant (P=0.042, P=0.040). Compared with before stimulation, the (δ+θ)/(α+β) frequency ratio of T7 channel in the true stimulation group decreased significantly after stimulation, the difference was statistically significant (P=0.041). Multivariate regression analysis showed that gender, age, body mass index, disease course and absolute power of the subjects had no statistical significance (all P>0.05).  Conclusion  After a single intervention of intermittent θ pulse stimulation, the absolute power of β-band of T7 and CP6 channels in the temporal region of type 2 diabetes mellitus patients with mild cognitive impairment was increased, and reduce the frequency ratio of the T7 channel. iTBS improves cognitive function by affecting cognitive processing in patients with type 2 diabetes with mild cognitive impairment.

     

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