Consistency analysis of contrast-enhanced ultrasonography and Magnetic resonance imaging in assessment of lesion size and invasion for cervical cancer

Objective To investigate the consistency of contrast-enhanced ultrasonography (CEUS) with MRI in assessing the lesion size and invasion of cervical cancer. Methods Seventy six patients with cervical cancer admitted to our hospital from January 2017 to November 2018 were enrolled into this study. MRI enhanced scan and CEUS were used to compare the size of the lesions and the consistency of the surrounding invasion. Results The consistency analysis showed that MRI and CEUS had good consistency in transverse diameter, longitudinal diameter and anteroposterior diameter of the lesion (ICC=0.949, 0.802, 0.866). There was no statistical difference between the mean differences (P=0.253, 0.744), and the CEUS lesions were significantly lower than the MRI (P=0.002). The diagnostic rate of CEUS and MRI for vaginal invasion was 88.16% with high agreement (Kappa=0.761). The concomitant rate of CEUS and MRI for the assessment of parametrical tissue invasion was 88.16% with high agreement (Kappa=0.799). The diagnostic agreement rate for CEUS and MRI assessment of bladder and rectal invasion was 77.63% with high agreement (Kappa=0.719). Conclusion Contrast-enhanced ultrasonography have a good agreement with MRI in assessing the size and invasion of cervical cancer, but CEUS showed similar moderate agreement with MRI in cranial-caudal diameter, bladder or rectal invasion.