Objective To investigate the effects of early intensive antihypertensive therapy on mass, inflammation and neurological function of patients with hypertensive intracerebral hemorrhage.
Methods One hundred and sixty-eight patients with cerebral hemorrhage admitted from January, 2014 to June, 2016 were randomly divided into two groups, with 84 cases in each group.Patients in control group were only given conventional treatment, by intravenous titration of Nitroglycerin to maintain systolic blood pressure from 160 to 180 mm Hg.Patients in observation group were given early enhanced treatment, by pumped Nitroglycerin to maintain systolic blood pressure from 130 to 140 mm Hg.The hematoma of two groups were measured by CT results, the inflammation levels (TNF-α, IL-1β, IL-6) of two groups were detected by Elisa methods, and neurological function of two groups were measured by National Institutes of Health Stroke Scale (NIHSS).The data were statistical analyzed to investigate the effects of early intensive antihypertensive therapy on mass, inflammation and neurological function of patients with hypertensive intracerebral hemorrhage.
Results After 1 d treatment, the hematoma volume of observation group was significantly lower than that of control group (
P < 0.05).The hematoma enlargement ratio of observation group was 8.3%, which was significantly lower than that of control group (20.8%) (
P <0.05).After 14 d treatment, the TNF-α, IL-1β and IL-6 levels of two groups were significantly reduced (
P < 0.05), and the TNF-α, IL-1β and IL-6 levels of observation group were significantly lower than those of control group (
P < 0.05).After 14 d treatment, the NIHSS level of two groups were significantly reduced (
P < 0.05), and the NIHSS level of observation group were significantly lower than those of control group (
P < 0.05).
Conclusion Early intensive antihypertensive therapy could improve the hematoma, inflammation and neurological function of patients with cerebral hemorrhage, with satisfactory effects.
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