Effects of sufentanil combined remifentanil on anesthesia and stress of patients with radical gastrectomy

Objective To investigate the effects of sufentanil combined remifentanil on anesthesia and stress of patients with radical gastrectomy. Methods Eighty-four patients with radical gastrectomy of Shaoxing people 's hospital from June, 2010 to May, 2014 were randomly divided into two groups, each group 42 cases.The control group was given remifentanil anesthesia, and the observation group was given sufentanil combined remifentanil anesthesia.The hemodynamics at before anesthesia (T1), before intubation (T2), 1 min after intubation (T3), 1 min after extubation (T4), 5 min after extubation (T5), Observer's assessment of alertness/sedation (OAA/S) scale and restless score (RS) at 10 min after extubation, VAS score at postoperative 6 h (T6), postoperative 12 h (T7) and postoperative 24 h (T8), norepinephrine (NE), adrenaline (E) levels at T1, T3, T4, T6, T7, T8 of two groups were compared. Results Compared with T1, the HR levels at T2 of two groups were significantly decreased (P < 0.05), HR levels at T3-T4 of two groups were significantly increased (P < 0.05), and HR levels at T3-T5 of observation group were significantly lower than those of control group (P < 0.05).Compared with T1, the MAP levels at T2 of two groups were significantly decreased (P < 0.05), MAP levels at T3-T5 of control group were significantly increased (P < 0.05), and MAP levels at T3-T5 of observation group were significantly lower than that of control group (P < 0.05).The OAA/S, RS, VAS scores of observation group were significantly lower than those of control group (P < 0.05).Compared with T1, the NE, E levels at T3-T4 of two groups were significantly increased (P < 0.05), NE, E levels at T7-T8 of two groups were significantly reduced (P < 0.05), and NE, E levels at T3, T4, T6, T7, T8 of observation group were significantly lower than those of control group (P < 0.05). Conclusion Compared to remifentanil alone, sufentanil combined remifentanil could effectively maintain hemodynamics, reduce pain and stress of patients with radical gastrectomy.