Objective To study the effect of levamlodipine on the serum levels of platelet-derived growth factor-BB (PDGF-BB) in patients with essential hypertension and its influence on carotid artery intima-media thickness (IMT).
Methods Ninety patients with essential hypertension who were visited in the cardiovascular clinic of the affiliated hospital of Panzhihua university from April 2014 to January 2016 were randomized into control group (
n=30), levamlodipine group (
n=30) and diuretics group (
n=30).All groups received the therapeutic lifestyle interventions, in addition, the levamlodipine group was administered with oral levamlodipine, diuretics group with oral diuretics.The serum levels of PDGF-BB and carotid artery IMT were determined.The serum levels of PDGF-BB and carotid artery IMT were analyzed by linear correlation before treatment.The changes in serum levels of PDGF-BB and carotid artery IMT were compared after 6and 12 months of treatment.
Results The serum level of PDGF-BB was moderately positively correlated with carotid artery IMT before the treatment.There were obviously decreased in the serum levels of PDGF-BB of the levamlodipine group after 6 months of treatment as compared with those before the treatment.There were no significant difference in the serum levels of PDGF-BB of the control group and diuretics group after 6 months of treatment as compared with those before the treatment.After 12 months of treatment, there was no significant difference in the serum levels of PDGF-BB of the control group as compared with those before the treatment and after 6 months of treatment.The serum levels of PDGF-BB of both levamlodipine group and diuretics group were evidently decreased as compared with those after 6 months.And the serum levels of PDGF-BB of the levamlodipine group were lower than the diuretics group.After 12 months of treatment, the carotid artery IMT of the control group was increased as compared with that before the treatment.The value in the diuretics group was unchanged;the carotid artery IMT of the levamlodipine group was decreased as compared with that before the treatment and after 6 months of treatment.
Conclusion In patients with essential hypertension, Levamlodipine may reduce the serum levels of PDGF-BB and carotid artery IMT, and the serum level of PDGF-BB is moderately positively correlated with carotid artery IMT.Levamlodipine may decline the carotid artery IMT through reducing the serum levels of PDGF-BB of essential hypertension.
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