Objective To study the left to right shunt congenital heart disease (congenital heart diseases, CHD) in children with heart failure when plasma amino-terminal B-type Natriuretic Peptide Precursor (Amino Terminal B-type Natriuretic Peptide, NT-pro BNP) changes and its value in the evaluation of cardiac function, analyze the correlation with modified Ross score, search for pediatric heart failure rapid detection methods.
Methods The object of study is 55 cases left to right shunt CHD patients.According to the modified Ross score, the patients were divided into four groups, and the before and after treatment were compared.An alternate 12 cases in the same period in the hospital without CHD and heart failure in children as control group.With the United States (Roche) rapid heart failure diagnosis instrument determination of all children with plasma NT-pro BNP level, analyze its significance.
Results The NT-pro BNP and modified Ross score into positive correlation (
r=0.859), the children with CHD NT-pro BNP level obviously higher than that of control group, with statistical significance (
P < 0.05), there were significant difference among heart failure group (
P < 0.05).Children with heart failure after treatment, plasma NT-pro BNP levels significantly decreased, with statistical significance (
P <0.001), the NT-pro BNP in the diagnosis of cardiac insufficiency of cutoff value was 286.5 pg/ml.
Conclusion Different degree of heart failure in children with NT-pro BNP have a significant difference, the plasma NT-pro BNP can be used as the infant left to right shunt CHD with heart failure an objective indicator of cardiac function evaluation.