Clinical study of preconditioned combined intraoperative recovering autologous blood transfusion in patients with elective surgery

Objective To investigate the clinical effect of preconditioned combined intraoperative recovering autologous blood transfusion in patients with elective surgery. Methods Eighty-four patients with elective surgery were randomly divided into two groups,each group 42 cases.Patients in control group were given allogeneic blood transfusion,and patients in observation group were given preoperative combined intraoperative recovery of autologous blood transfusion.Before and after treatment,the blood related indicators (Hb,Hct,PLT,PT,APTT),inflammatory mediators (TNF-α,complement C3),peripheral blood T lymphocyte subsets (CD4,CD4/CD8,CD8) and NK cells,immunoglobulin (IgA,IgG,IgM) of patients were detected,and the adverse reactions were accounted. Results After treatment,Hb,HCT,PLT,PT and APTT levels of observation group had no significantly differences compared to before treatment (P>0.05).Hb,HCT,PLT,PT and APTT levels of control group were significantly decreased compared to before treatment (P<0.05).After treatment,Hb,HCT,PLT,PT and APTT levels of observation group were significantly higher than those of control group (P<0.05).After treatment,complement C3,CD4,CD4/CD8,NK cells,IgA,IgG,IgM of observation group were significantly higher than those of before treatment (P<0.05).After treatment,complement C3,CD4,CD4/CD8,NK cells,IgA,IgG,IgM of control group were significantly lower than those of before treatment (P<0.05).After treatment,complement C3,CD4,CD4/CD8,NK cells,IgA,IgG,IgM of observation group were significantly higher than those of control group (P<0.05).After treatment,TNF-α of observation group was significantly lower than that of before treatment (P<0.05).After treatment,TNF-α of control group was significantly higher than that of before treatment (P<0.05).After treatment,TNF-α of observation group was significantly lower than that of control group (P<0.05).The adverse reaction rate of observation group was 0.0%,which was significantly lower than that of control group (14.3%,P<0.05). Conclusion Compared to allogeneic blood transfusion,preoperative combined intraoperative recovery of autologous blood transfusion could effectively regulate the inflammation and immune function,is helpful for prognosis recovery.