Objective To investigate the relationship between renal pathological classifications,activity index (AI),chronicity index (CI) in Lupus nephritis and clinical parameters,as well laboratory index.
Methods Ninety-six LN patients with kidney biopsy were collected from February,2011 to March,2014.The retrospective analyses were conducted for the correlations between pathological manifestations and clinical,laboratory index.
Results ①According to ISN/RDS in 2003,out of 96 LN patients,none of case was categorized as LN-Ⅰ,9 cases (9.38%) were belonged to LN-Ⅱ,9 cases (9.38%) were classified as LN-Ⅲ,67 cases (69.79%) were LN-Ⅳ,11 cases (11.46%) were LN-Ⅴ.②SLEDAI,AI,CI in LN patients were obviously different among different pathological types,LSD test Results showed that AI in LN-Ⅳ were higher than that in LN-Ⅱ,LN-Ⅲ and LN-Ⅴ(
P<0.0 001).CI in LN-Ⅳ were higher than that in LN-Ⅱ(
P<0.05).SLEDAI in LN-Ⅳ were elevated than LN-Ⅱ and LN-Ⅲ(
P<0.05).③Along with the increasing of SLEDAI in LN patients,AI gradually raised (
F=15.469,
P<0.001).There were no statistic difference regarding CI among patients with different SLEDAI (
F=0.442,
P=0.724).④Urine protein level in LN-Ⅳ was remarkable higher than that in LN-Ⅱ and LN-Ⅴ(
F=1.348,
P=0.002;
F=0.894,
P=0.022).Serum uric acid level in LN-Ⅳ was higher than that in LN-Ⅱ and LN-Ⅴ(
F=98.396,
P=0.011;
F=72.063,
P=0.040).⑤Results showed that AI was positively correlated with SLEDAI,urine protein,24 hour urinary protein,ACL,ANA and anti-C1q antibody levels (
P<0.05-0.001),while negatively associated with serum C3,C4 and HB levels (
P<0.05).There was a positive correlations between CI and urine protein,a negative correlations between CI and amount of urine uric acid in 24 hours (
P<0.05).
Conclusion The pathological type in patients with LN and AI,CI are closely related with clinical and laboratory indexes.We should emphasis the value of SLEDAI and serum C3 on indicating AI in pathological manifestation.
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