Meta-analysis of Vitamin E supplement on preventive effect of myocardial infarction

Objective To explore the effect of vitamin E on the protection on myocardial infarction by conducting meta-analysis. Methods Data base of Web of science,Pub Med and Embase were searched for all related articles about the protection of vitamin E on myocardial infarction.The search work stopped on May of 2015.According to the including and excluding criteria,two investigators choose the matched trials.Combined with quality evaluation,acquired the available information.Utilized Meta-analysis to assess selected studies and affiliated data.We utilized Review Manager 5.0 to statistic all data. Results Five studies were randomized controlled trials articles.87 296 individuals were(43 647 individuals were in test group and 43 649 individuals were in control group) analyzed and base line of two groups were comparable.The results of system assessment suggested that there was no significant difference on the protective effect of vitamin E on myocardial infarction[RR=0.94,95% CI(0.82,1.08)，P=0.39].Sensitivity analysis indicated that the result did not reverse when deleting a study[RR=1.01,95% CI(0.94,1.08)，P=0.74]，[RR=0.97,95% CI(0.86,1.09)，P=0.58]，[RR=0.91,95% CI(0.76,1.09)，P=0.31]，[RR=0.88,95% CI(0.73,1.07)，P=0.19]，[RR=0.90,95%CI(0.72,1.12)，P=0.34].The infundibulum figure showed publication bias was small and the result was credible. Conclusion There is no direct evidence for the preventive role of vitamin E on myocardial infarction.