Volume 23 Issue 8
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(8): 1404-1410
Aikebaierjiang·Aisaiti, Abduwupur·Haibeier, GU Wenzhu, Kutiluke·Shoukeer, Shalayiding·Aierxidin, Alimujan·Abudurousuli, LUO Xuefeng. Meta-analysis of the efficacy and safety of tranexamic acid in the perioperative period of posterior lumbar fusion[J]. Chinese Journal of General Practice, 2025, 23(8): 1404-1410. doi: 10.16766/j.cnki.issn.1674-4152.004144
Citation: Aikebaierjiang·Aisaiti, Abduwupur·Haibeier, GU Wenzhu, Kutiluke·Shoukeer, Shalayiding·Aierxidin, Alimujan·Abudurousuli, LUO Xuefeng. Meta-analysis of the efficacy and safety of tranexamic acid in the perioperative period of posterior lumbar fusion[J]. Chinese Journal of General Practice, 2025, 23(8): 1404-1410. doi: 10.16766/j.cnki.issn.1674-4152.004144
shu

Meta-analysis of the efficacy and safety of tranexamic acid in the perioperative period of posterior lumbar fusion

doi: 10.16766/j.cnki.issn.1674-4152.004144
  • 1.

    Department of Orthopedics, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830002, China

Funds:

 82260252

 8237152292

 2022D01C221

 2022YFY-QKQN-21

 2022E02128

  • Received Date: 2024-08-15
    Available Online: 2025-10-31
    Abstract
  •   Objective  To conduct a meta-analysis assessing the effectiveness and safety of tranexamic acid (TXA) during the perioperative period of posterior lumbar interbody fusion (PLIF), investigating its role in reducing surgical bleeding and promoting patient recovery.  Methods  PubMed, Cochrane Library, EMbase, CNKI, Wanfang, and VIP databases were searched for randomized controlled trials of tranexamic acid in the perioperative period of PLIF, and 22 studies (2 577 patients, 1 300 tranexamic acid group and 1 277 control group) were selected. Endnote X9 was used to organize the literature, Revman 5.3 software was used to analyze the data, and the detection indicators covered intraoperative blood loss, total blood loss, etc.  Results  The application of TXA to PLIF significantly reduced intraoperative and total blood loss and postoperative drainage, shortened the operation time, reduced the blood transfusion rate compared to the control group, and also reduced the postoperative hemoglobin loss and hematocrit, shortened the hospital stay, and did not increase the risk of postoperative complications.  Conclusion  The application of TXA in the perioperative period of PLIF can reduce the related blood loss and blood transfusion rate, shorten the operation time, improve the change of indicators, and does not increase the risk of postoperative complications, which supports clinical promotion.

     

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