Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure

HE Shijia; LIANG Ying; ZHU Hongtao

doi:10.16766/j.cnki.issn.1674-4152.004129

Volume 23 Issue 8

Aug. 2025

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2025 > 23(8): 1340-1342

HE Shijia, LIANG Ying, ZHU Hongtao. Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure[J]. Chinese Journal of General Practice, 2025, 23(8): 1340-1342. doi: 10.16766/j.cnki.issn.1674-4152.004129

Citation:

HE Shijia, LIANG Ying, ZHU Hongtao. Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure[J]. Chinese Journal of General Practice, 2025, 23(8): 1340-1342. doi: 10.16766/j.cnki.issn.1674-4152.004129

Citation:

PDF( 405 KB)

Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure

doi: 10.16766/j.cnki.issn.1674-4152.004129

HE Shijia¹
, LIANG Ying²
, ZHU Hongtao^{1
,
,}

1.
Department of Pediatrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjing 830000, China

Funds:

2019D01C224

Received Date: 2025-02-11
Available Online: 2025-10-31

Abstract

Abstract

Objective To analyze the clinical characteristics of children with severe pneumonia complicated with respiratory failure, find out the influencing factors of poor prognosis, and reduce its occurrence. Methods A total of 110 children with severe pneumonia complicated with respiratory failure admitted to the First Affiliated Hospital of Xinjiang Medical University from December 2020 to December 2022 were divided into a good prognosis group (82 cases) and a poor prognosis group (28 cases) according to the prognosis. The clinical data of children were collected, and the influencing factors of poor prognosis were analyzed by logistic regression. Results Pulmonary function decreased and arterial blood gas worsened in the poor prognosis group. Logistic regression analysis showed that age ≤3 years (OR=1.292, 95% CI: 1.068-1.516), repeated respiratory tract infection (OR=3.904, 95% CI: 3.414-4.394), acute physiology and chronic health evaluation-Ⅱ score (APACHE Ⅱ) score ≥18 points (OR=4.702, 95% CI: 4.024-5.380), non-ventilation therapy (OR=2.004, 95% CI: 1.594-2.414), persistent pulmonary hypertension (OR=4.600, 95% CI: 3.884-5.316), malnutrition (OR=5.212, 95% CI: 4.548-5.876), hypoxemia (OR=5.557, 95% CI: 4.715-6.399), repeated intubation (OR=5.114, 95% CI: 4.450-5.778), hypercapnia (OR=3.501, 95% CI: 2.897-4.105), immunosuppression (OR=3.789, 95% CI: 3.065-4.513) were the risk factors for poor prognosis (P<0.05). Conclusion Respiratory failure in children with severe pneumonia can damage their lung function. Clinical analysis of its risk factors and intervention can improve its prognosis.
- Severe pneumonia,
- Respiratory failure,
- Lung function,
- Influencing factor

FullText(HTML)

References(22)

References

[1]	QU J, ZHANG J, CHEN Y, et al. Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China[J]. Emerg Microbes Infect, 2022, 11(1): 556-566. doi: 10.1080/22221751.2022.2035194
[2]	POVOA P, COELHO L, SALLUH J. When should we use corticosteroids in severe community-acquired pneumonia?[J]. Curr Opin Infect Dis, 2021, 34(2): 169-174. doi: 10.1097/QCO.0000000000000709
[3]	RAMPON G L, SIMPSON S Q, AGRAWAL R. Prone positioning for acute hypoxemic respiratory failure and ards: a review[J]. Chest, 2023, 163(2): 332-340. doi: 10.1016/j.chest.2022.09.020
[4]	BOUADMA L, MEKONTSO-DESSAP A, BURDET C, et al. High-dose dexamethasone and oxygen support strategies in intensive care unit patients with severe COVID-19 acute hypoxemic respiratory failure: the COVIDICUS randomized clinical trial[J]. JAMA Intern Med, 2022, 182(9): 906-916. doi: 10.1001/jamainternmed.2022.2168
[5]	URNER M, BARNETT A G, BASSI G L, et al. Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study[J]. BMJ, 2022, 377(8): 68-72.
[6]	江载芳. 实用小儿呼吸病学[M]. 北京: 人民卫生出版社, 2010. JIANG Z F. Practical pediatric respiratory diseases[M]. Beijing: People's Medical Publishing House, 2010.
[7]	蒋玉麟, 潘家华, 吴圣楣. 现代实用儿科诊疗指南[M]. 合肥: 安徽科学技术出版社, 2007. JIANG Y L, PAN J H, WU S M. Modern practical pediatric diagnosis and treatment guide[M]. Hefei: Anhui Science and Technology Press, 2007.
[8]	刘瑶, 吴金桓, 范铭兴, 等. 动态监测降钙素原对重症社区获得性肺炎患儿抗感染治疗的临床研究[J]. 中华全科医学, 2023, 21(2): 186-189. doi: 10.16766/j.cnki.issn.1674-4152.002841 LIU Y, WU J H, FAN M X, et al. Clinical study of dynamic monitoring of procalcitonin for anti-infection treatment of severe community-acquired pneumonia in children[J]. Chinese Journal of General Practice, 2023, 21(2): 186-189. doi: 10.16766/j.cnki.issn.1674-4152.002841
[9]	MAHMOODPOOR A, SHADVAR K, SANAIE S, et al. Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study[J]. BMC Infect Dis, 2021, 21(1): 616-618. doi: 10.1186/s12879-021-06288-0
[10]	雷勋明, 谢娜, 李尚文. 早期NCPAP对重症肺炎并呼吸衰竭患儿血气指标及PCIS的影响[J]. 湖北医药学院学报, 2020, 39(4): 381-383. LEI X M, XIE N, LI S W. Effect of early NCPAP on blood gas index and PCIS in children with severe pneumonia and respiratory failure[J]. Journal of Hubei University of Medicine, 2020, 39(4): 381-383.
[11]	石丹英, 张红英. 加温湿化高流量鼻导管氧疗与nCPAP在小儿重症肺炎呼吸衰竭辅助治疗中的应用对比观察[J]. 山东医药, 2021, 61(18): 69-71. SHI D Y, ZHANG H Y. Comparative observation on the application of warm humidified high flow nasal catheter oxygen therapy and nCPAP in the adjuvant treatment of respiratory failure in children with severe pneumonia[J]. Shandong Medical Journal, 2021, 61(18): 69-71.
[12]	冷凌涵, 陈浩, 宋佳平, 等. 有创-无创序贯机械通气与传统有创机械通气治疗重症肺炎合并呼吸衰竭的疗效对比研究及院内死亡的危险因素分析[J]. 现代生物医学进展, 2022, 22(23): 4576-4580, 4559. LENG L H, CHEN H, SONG J P, et al. Comparative study on the efficacy of invasive and non-invasive sequential mechanical ventilation and traditional invasive mechanical ventilation in the treatment of severe pneumonia complicated with respiratory failure and risk factors of hospital death[J]. Progress in Modern Biomedicine, 2022, 22(23): 4576-4580, 4559.
[13]	张敏, 郑贵兰. 异常表达的PVT1作为诊断标志物预测重症肺炎合并呼吸衰竭患儿临床结局的研究[J]. 东南大学学报(医学版), 2022, 41(1): 63-69. ZHANG M, ZHENG G L. Abnormal expression of PVT1 as a diagnostic marker to predict the clinical outcome of children with severe pneumonia complicated with respiratory failure[J]. Journal of Southeast University (Medical Science Edition), 2022, 41(1): 63-69.
[14]	周巍玲, 魏升云, 张孝兴. 经鼻持续气道正压通气联合丙种球蛋白治疗儿童重症肺炎并呼吸衰竭疗效的影响因素[J]. 中国妇幼健康研究, 2022, 33(2): 76-80. ZHOU W L, WEI S Y, ZHANG X X. Effect of nasal continuous positive airway pressure combined with gamma globulin in the treatment of severe pneumonia and respiratory failure in children[J]. Chinese Research on Maternal and Child Health, 2022, 33(2): 76-80.
[15]	闫智慧, 王亚坤, 董伟然, 等. 呼吸道合胞病毒感染肺炎患儿发生重症肺炎的影响因素[J]. 中国医师杂志, 2023, 25(1): 56-60. YAN Z H, WANG Y K, DONG W R, et al. Influencing factors of severe pneumonia in children with respiratory syncytial virus infection[J]. Chinese Journal of Physicians, 2023, 25(1): 56-60.
[16]	王文志. 重症肺炎患儿并发心力衰竭的危险因素分析[J]. 检验医学与临床, 2022, 19(17): 2389-2392, 2397. WANG W Z. Analysis of risk factors of heart failure in children with severe pneumonia[J]. Lab Med Clin, 2022, 19(17): 2389-2392, 2397.
[17]	张云霞, 阮联英, 王征军, 等. 重症肺炎伴呼吸衰竭患儿的临床治疗及VAP感染病原菌与危险因素分析[J]. 中华医院感染学杂志, 2019, 29(7): 1102-1105. ZHANG Y X, RUAN L Y, WANG Z J, et al. Clinical treatment of severe pneumonia with respiratory failure and analysis of pathogenic bacteria and risk factors of VAP infection[J]. Chinese Journal of Nosocomiology, 2019, 29(7): 1102-1105.
[18]	刘锦茂, 张小林, 胡敏. 血清C反应蛋白、前白蛋白和红细胞体积分布宽度对重症肺炎合并呼吸衰竭患者预后的预测价值[J]. 临床与病理杂志, 2023, 43(1): 22-28. LIU J M, ZHANG X L, HU M. Prognostic value of serum C-reactive protein, prealbumin and erythrocyte volume distribution width in patients with severe pneumonia complicated with respiratory failure[J]. J Clin Pathol Res, 2023, 43(1): 22-28.
[19]	张洋. 鼻塞式持续气道正压通气治疗小儿重症肺炎的疗效及影响因素分析[J]. 中国妇幼保健, 2020, 35(11): 2034-2036. ZHANG Y. Analysis of curative effect and influencing factors of nasal continuous positive airway pressure ventilation in the treatment of severe pneumonia in children[J]. Child Health Care of China, 2020, 35(11): 2034-2036.
[20]	程远, 解启莲, 赵胜, 等. 百日咳相关性重症肺炎患儿行有创机械通气的影响因素分析[J]. 中国医药, 2022, 17(12): 1787-1790. CHENG Y, XIE Q L, ZHAO S, et al. Influencing factors of invasive mechanical ventilation in children with pertussis associated severe pneumonia[J]. China Medicine, 2022, 17(12): 1787-1790.
[21]	MAHMOODPOOR A, SHADVAR K, SANAIE S, et al. Effect of vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study[J]. BMC Infect Dis, 2021, 21(1): 616. doi: 10.1186/s12879-021-06288-0
[22]	SAI T A, TSAI C K, KUO K C, et al. Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children[J]. J Microbiol Immunol Infect, 2021, 54(4): 557-565. doi: 10.1016/j.jmii.2020.10.002

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(5)

Get Citation

PDF

XML

Article Metrics

Article views (3) PDF downloads(1)

Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure

doi: 10.16766/j.cnki.issn.1674-4152.004129

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Analysis of the prognosis and related influencing factors in children with severe pneumonia combined with respiratory failure

doi: 10.16766/j.cnki.issn.1674-4152.004129

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content