Volume 23 Issue 8
Aug.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(8): 1333-1336
WANG Xiaohua, WANG Jun, LI Li, GAO Qian. Diagnostic value of ESM-1 and PTX3 in elderly patients with diabetic nephropathy complicated with pulmonary infection[J]. Chinese Journal of General Practice, 2025, 23(8): 1333-1336. doi: 10.16766/j.cnki.issn.1674-4152.004127
Citation: WANG Xiaohua, WANG Jun, LI Li, GAO Qian. Diagnostic value of ESM-1 and PTX3 in elderly patients with diabetic nephropathy complicated with pulmonary infection[J]. Chinese Journal of General Practice, 2025, 23(8): 1333-1336. doi: 10.16766/j.cnki.issn.1674-4152.004127
shu

Diagnostic value of ESM-1 and PTX3 in elderly patients with diabetic nephropathy complicated with pulmonary infection

doi: 10.16766/j.cnki.issn.1674-4152.004127

  • Department of Geriatrics, Affiliated Hospital of Shaoxing University of Arts and Sciences, Shaoxing, Zhejiang 312000, China

Funds:

 2024KY1739

  • Received Date: 2025-01-09
    Available Online: 2025-10-31
    Abstract
  •   Objective  To analyze the diagnostic value of endothelium-specific molecule-1 (ESM-1) and pentamerin-3 (PTX3) in elderly patients with diabetic nephropathy (DN) complicated with pulmonary infection, and to provide more valuable prognostic indicators for the improvement of patient prognosis.  Methods  A total of 81 patients with DN admitted to the Affiliated Hospital of Shaoxing University of Arts and Sciences from October 2020 to October 2023 were selected and divided into DN group with pulmonary infection (n=36) and DN group (n=45) according to whether they had pulmonary infection. Serum ESM-1 and PTX3 levels of the patients were detected. ROC curve was drawn to evaluate the diagnostic value of ESM-1 and PTX3 in elderly patients with DN complicated with pulmonary infection.  Results  The levels of serum ESM-1 and PTX3 were (5.64±1.24) ng/mL and (203.57±44.86) ng/mL in the DN group complicated with pulmonary infection. They were higher than those in DN group [(3.91±1.11) ng/mL, (148.44±39.95) ng/mL, t=6.616, 5.843, P<0.001]. The results of multivariate logistic regression analysis showed that long duration of DM, high fasting blood glucose level, low serum albumin level, high HbA1c value, history of COPD, maintenance hemodialysis, renal decompensation, high ESM-1 level and high PTX3 level were independent risk factors for pulmonary infection in elderly patients with DN (P<0.05). ROC curve analysis indicated that the AUCs of ESM-1 and PTX3 in the diagnosis of pulmonary infection in elderly DN patients were 0.834 and 0.862 respectively, and the AUC of combined diagnosis was 0.929.  Conclusion  Serum ESM-1 and PTX3 levels in elderly patients with DN complicated with pulmonary infection are significantly increased. The detection of the two levels is helpful to the diagnosis of pulmonary infection in elderly patients with DN.

     

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