Volume 23 Issue 8
Aug.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(8): 1289-1291
DU Jiang, WANG Meixia, TAO Zhuang, HAO Wenjie, WANG Fei, ZHANG Yu, YANG Pingping. Correlation between Child-Pugh classification and electrocardiogram variation in patients of Wilson ' s disease with cirrhosis[J]. Chinese Journal of General Practice, 2025, 23(8): 1289-1291. doi: 10.16766/j.cnki.issn.1674-4152.004117
Citation: DU Jiang, WANG Meixia, TAO Zhuang, HAO Wenjie, WANG Fei, ZHANG Yu, YANG Pingping. Correlation between Child-Pugh classification and electrocardiogram variation in patients of Wilson ' s disease with cirrhosis[J]. Chinese Journal of General Practice, 2025, 23(8): 1289-1291. doi: 10.16766/j.cnki.issn.1674-4152.004117
shu

Correlation between Child-Pugh classification and electrocardiogram variation in patients of Wilson ' s disease with cirrhosis

doi: 10.16766/j.cnki.issn.1674-4152.004117
  • 1.

    The First Clinical Medical College of Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230031, China

Funds:

 皖中医药发展秘〔2024〕1号

 国中医药人教函〔2022〕256号

 中发展〔2022〕4号

 2023AH050798

 2023AH050765

 发改办社会〔2022〕366号

  • Received Date: 2024-10-11
    Available Online: 2025-10-31
    Abstract
  •   Objective   To compare the related parameters of Child-Pugh classification and cardiac function in patients with hepatolenticular degeneration and cirrhosis, and to explore the variation of electrocardiogram in the very early stage of these patients.   Methods   A total of 98 patients with hepatolenticular degeneration and cirrhosis admitted to Anhui Provincial Hospital of Traditional Chinese Medicine from June 2022 to July 2023 were selected as the observation group. The Child-Pugh score was calculated and divided into three subgroups: A, B and C according to its classification. A total of 98 cases of physical examination in the hospital during the same period were selected as the control group. The electrocardiogram parameters of the two groups were collected and compared to explore the correlation between Child-Pugh classification and electrocardiogram variation in WD patients.   Results   (1) The abnormal rate of electrocardiogram in the observation group (84.69%) was higher than that in the control group (25.51%), and the difference was statistically significant (P < 0.05). (2) Compared with the control group [(68.11±3.95) times/min, (91.09±4.55) ms], the heart rate and QRS duration of the observation group [(75.57±6.56) times/min, (102.23±7.98) ms] were prolonged, and the difference was statistically significant (P < 0.01). (3) Compared with subgroup A, the heart rate of subgroup B and subgroup C was accelerated, the QRS duration, QT and QTc interval were prolonged, and the difference was statistically significant (P < 0.01). (4) Spearman correlation analysis showed that Child-Pugh classification was positively correlated with heart rate (r=0.740, P < 0.001), QRS duration (r=0.495, P < 0.001), QT interval (r=0.442, P < 0.001), QTc interval (r=0.490, P < 0.001), and negatively correlated with P-R interval (r=-0.433, P < 0.001).   Conclusion   Patients with hepatolenticular degeneration and cirrhosis are more likely to have non-specific ECG abnormalities than normal people. There is a certain relationship between the severity of liver cirrhosis and its electrocardiogram variability.

     

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