Volume 23 Issue 8
Aug.  2025
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Article Navigation >  Chinese Journal of General Practice  > 2025  >  23(8): 1280-1283
ZOU Yitong, CHENG Yisheng, WANG Peipei. Based on the model of double difference method, this paper analyzes the influence of Tiaoren Tongdu acupuncture on patients with cognitive impairment after stroke[J]. Chinese Journal of General Practice, 2025, 23(8): 1280-1283. doi: 10.16766/j.cnki.issn.1674-4152.004115
Citation: ZOU Yitong, CHENG Yisheng, WANG Peipei. Based on the model of double difference method, this paper analyzes the influence of Tiaoren Tongdu acupuncture on patients with cognitive impairment after stroke[J]. Chinese Journal of General Practice, 2025, 23(8): 1280-1283. doi: 10.16766/j.cnki.issn.1674-4152.004115
shu

Based on the model of double difference method, this paper analyzes the influence of Tiaoren Tongdu acupuncture on patients with cognitive impairment after stroke

doi: 10.16766/j.cnki.issn.1674-4152.004115
  • 1.

    Department of Hyperbaric Oxygen, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2020ZB241

 Y20220556

  • Received Date: 2024-09-26
    Available Online: 2025-10-31
    Abstract
  •   Objective   To evaluate the therapeutic effect of Tiaoren Tongdu acupuncture combined with hyperbaric oxygen on patients with post-stroke cognitive impairment (PSCI), and to analyze the influence on cognitive function of patients by the double difference method (DID) model.   Methods   According to the random number table method, 126 patients with PSCI admitted to Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from May 2020 to July 2023 were divided into two groups. The routine group (n=57) was given hyperbaric oxygen therapy, and the combined group (n=59) was Tiaoren Tongdu acupuncture therapy on the basis of the routine group. After the treatment, the clinical efficacy, inflammatory factor level, cerebral blood flow perfusion, and cognitive function were compared between the two groups.   Results   The total effective rate of the combined group (93.22%, 55/59) was higher than that of the routine group (80.70%, 46/57, P < 0.05). After two months of treatment, the levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and IL-10 in the combined group were lower than those in the conventional group (P < 0.05). The cerebral blood flow (CBF) and cerebral blood volume (CBV) in the combined group were higher than those in the routine group, while the mean transit time (MTT) and time to peak (TTP) were lower than those in the routine group (P < 0.05). After 1 week of treatment, 1 month of treatment, 2 months of treatment, and the end of follow-up, the Montreal cognitive assessment score in the combined group was higher than that in the routine group (P < 0.05). The DID regression model showed that after treatment, the cognitive function of patients increased by 1 134.2% respectively (P < 0.05).   Conclusion   The Tiaoren Tongdu acupuncture combined with hyperbaric oxygen can reduce neuroinflammatory reaction, regulate cerebral blood flow, improve cognitive function, and relieve clinical symptoms in patients with cognitive impairment after stroke.

     

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